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CPT:
86695
Test Includes
Detection of antibodies specific to herpes type 1 only
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Testing Options to Support Diagnosis and Screening of Herpes Simplex Virus (HSV)
Specimen Requirements
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Refrigerate.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 2 days |
Refrigerated | 7 days |
Frozen | 98 days at -25°C to -10°C |
Test Details
Use
Qualititative detection of IgG antibodies specific to HSV type 1 infection; confirm or rule out possible infection with herpes simplex type 1 virus in prenatal patients. In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample.
Methodology
Chemiluminescent immunoassay (CLIA)
Reference Interval
Negative: <0.91 index
Additional Information
There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly cross-reactive. This assay is based on purified recombinant glycoprotein G-1 and is specific for type 1 antibodies. Moreover, this assay is highly sensitive and specific and will not detect antibodies to HSV-2.
Test is set up and reported Monday through Friday.
References
Ashley R, Cent A, Maggs V, Nahmias A, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 and 2. Ann Intern Med. 1991 Oct 1;115(7):520-526.1652909
Centers for Disease Control and Prevention. Sexually-transmitted disease treatment guidelines, 2015. MMWR. 2015;64(3).26042815
Corey L. The current trend in genital herpes. Progress in prevention. Sex Transm Dis. 1994 Mar-Apr;21(2 Suppl):S38-S44.8042114
Whitley RJ. Herpes simplex infections of women and their offspring: Implications for a developed society. Proc Natl Acad Sci USA, 1994 Mar 29;91(7):2441-2447 (review).8146137
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 164897 | HSV Type 1-Specific Ab, IgG | 5206-8 | 164903 | HSV 1 IgG, Type Spec | index | 5206-8 |
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