Herpes Simplex Virus (HSV) Type 1-Specific Antibodies, IgG

CPT: 86695
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Test Details

Test Includes

Detection of antibodies specific to herpes type 1 only

Use

Qualititative detection of IgG antibodies specific to HSV type 1 infection; confirm or rule out possible infection with herpes simplex type 1 virus in prenatal patients. In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample.

Methodology

Chemiluminescent immunoassay (CLIA)

Reference Interval

Negative: <0.91 index

Additional Information

There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly cross-reactive. This assay is based on purified recombinant glycoprotein G-1 and is specific for type 1 antibodies. Moreover, this assay is highly sensitive and specific and will not detect antibodies to HSV-2.

Test is set up and reported Monday through Friday.

Specimen Requirements

Specimen

Serum

Volume

0.5 mL

Minimum Volume

0.2 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Refrigerate.

Stability Requirements

Temperature

Period

Room temperature

2 days

Refrigerated

7 days

Frozen

98 days at -25°C to -10°C

Clinical Information

References

Ashley R, Cent A, Maggs V, Nahmias A, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 and 2. Ann Intern Med. 1991 Oct 1;115(7):520-526.1652909
Centers for Disease Control and Prevention. Sexually-transmitted disease treatment guidelines, 2015. MMWR. 2015;64(3).26042815
Corey L. The current trend in genital herpes. Progress in prevention. Sex Transm Dis. 1994 Mar-Apr;21(2 Suppl):S38-S44.8042114
Whitley RJ. Herpes simplex infections of women and their offspring: Implications for a developed society. Proc Natl Acad Sci USA, 1994 Mar 29;91(7):2441-2447 (review).8146137

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164897 HSV Type 1-Specific Ab, IgG 5206-8 164903 HSV 1 IgG, Type Spec index 5206-8

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf