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HER-2/neu Immunohistochemistry (IHC), Gastric Paraffin
HER-2-positive carcinomas predict response to humanized monoclonal antibody trastuzumab (Herceptin®) in conjunction with chemotherapy in patients with advanced or metastatic gastric or gastro-esphageal junction carcinoma.
Use of fixatives other than 10% formalin, fixation times less than six hours or greater than 48 hours may not yield reliable results.
Tumor (formalin-fixed, paraffin-embedded)
One paraffin block or five unstained, positively charged tissue slides cut at 4 to 5 microns and dried for one hour at 60°C.
FFPE tissue, preserved in 10% neutral buffered formalin, fixed for 18 to 24 hours. ASCO/CAP 2013 guidelines recommend fixation time between six and 72 hours for breast tissue; however, special ASCO/CAP guidelines have not been established for gastric cancer samples.
Maintain specimen at room temperature.
Causes for Rejection
Tumor other than gastric tumor
Please direct any questions regarding this test to oncology customer service at 800-345-4363. Please note: fixation time and fixative used must be indicated on the test request form.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|480226||HER-2/neu IHC,Gastric,Paraffin||480423||HER-2/neu (C-erbB-2)||18474-7|
|480226||HER-2/neu IHC,Gastric,Paraffin||480424||Scoring Guide||N/A|
|480226||HER-2/neu IHC,Gastric,Paraffin||483318||Fixation Time||N/A|
|480226||HER-2/neu IHC,Gastric,Paraffin||480232||Director Review||69426-5|