Hepatitis C Virus (HCV) Genotyping With 1a Subtype Reflex to Hepatitis C Virus (HCV) NS5A Drug Resistance Assay

CPT: 87902. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Details


Genotyping of the six major HCV types and their most common subtypes. Assessment of drug susceptibility by nucleic acid sequencing of a patient's hepatitis C virus (HCV) to the NS5A inhibitors. Detects resistance-associated variants at positions 28, 30, 31, and 93 in genotype 1a HCV.


The HCV genotype determination may not be successful when the HCV viral load is <1000 IU/mL serum/plasma. The HCV NS5A drug resistance assay will only be performed when the HCV genotype is 1a.


Polymerase chain reaction (PCR) amplification and solid-phase electrochemical detection

Specimen Requirements


Plasma (preferred) or serum, frozen


3 mL

Minimum Volume

2 mL


Ship in plasma preparation tubes (PPT™) or screw-capped polypropylene frozen transport tubes.


Collect specimen in two PPT™ tubes, gel-barrier tubes, yellow-top (ACD) tubes, or lavender-top (EDTA) tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection, remove serum/plasma, and transfer specimen to polypropylene screw-capped tubes, and freeze. Specimens drawn into PPT™ tubes need to be centrifuged within six hours and frozen. Ship frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Causes for Rejection

Hemolysis; green-top (heparin) tube; specimen not frozen on date of collection; PPT™ not centrifuged; specimen received in "pop-top" or "snap-cap" tube; specimen shipped at room temperature

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