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Hepatitis C Virus (HCV) GenoSure® NS3/4A
- HCV Drug Resistance
- NS3/4 Resistance Analysis
- Q80K Polymorphism
Assessment of drug susceptibility by nucleic acid sequencing of a patient's hepatitis C virus (HCV) to the NS3/4A protease inhibitors. Detects Q80K polymorphism. Assay should be used for patients with documented HCV genotype 1.
This procedure may not be successful when the viral load is <2000 IU/mL. This assay requires an HCV genotype of either 1a or 1b.
Polymerase chain reaction (PCR) amplification and DNA next generation sequencing
Plasma (preferred) or serum, frozen
Collect specimen in two PPT™ tubes, gel-barrier tubes, or lavender-top (EDTA) tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection, remove serum/plasma, and transfer specimen to polypropylene screw-capped tubes, and freeze. Specimens drawn into PPT™ tubes need to be centrifuged within six hours and frozen. Ship frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Causes for Rejection
PPT™ not centrifuged; insufficient volume; heparinized plasma; nonfrozen specimens; specimens exposed to repeated freeze/thaw cycles; specimen received in "pop-top" or "snap-cap" tube
Please indicate the patient's HCV genotype (1a or 1b) on the test request form.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|550540||HCV GenoSure(R) NS3/4A||550544||HCV GenoSure(R) NS3/4A PDF||32286-7|
|550540||HCV GenoSure(R) NS3/4A||550545||HCV GenoSure(R) NS3/4A||32286-7|
|550540||HCV GenoSure(R) NS3/4A||550546||HCV GenoSure(R) NS3/4A Interp||77202-0|
|550540||HCV GenoSure(R) NS3/4A||550547||HCV GenoSure(R) NS3/4A||N/A|