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Hepatitis B Virus (HBV) Genotyping Plus Drug Resistance
- HBV Genotype, PreCore and Resistance
- HBV Resistance Testing
Data generated in the genotyping assay is subsequently analyzed for mutations in the reverse transcriptase gene of HBV associated with resistance to therapeutic agents, and if identified an interpretation of their clinical significance provided.
This assay may not be successful when the HBV viral load is <500 IU/mL.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.
Polymerase chain reaction (PCR) amplification and DNA sequencing
Plasma or serum, frozen
Gel-barrier tube, yellow-top (ACD) tube, lavender-top (EDTA) tube or PPT.
Centrifuge sample within six hours of collection, transfer plasma/serum to a polypropylene screw-cap tube and freeze. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Causes for Rejection
Quantity not sufficient for analysis; heparin/SPS plasma (wrong anticoagulant); gross hemolysis; specimen not frozen
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|551750||HBV Genotype + Drug Resistance||551535||**HBV Genotype||32366-7|
|551750||HBV Genotype + Drug Resistance||551536||**HBV PreCore Mutation||54210-0|
|551750||HBV Genotype + Drug Resistance||551537||**HBV Drug Resistance Mutation||43279-9|
|551750||HBV Genotype + Drug Resistance||551538||**3TC [Lamivudine, Epivir]||30283-6|
|551750||HBV Genotype + Drug Resistance||551539||**ADV [Adefovir, Hepsera]||30288-5|
|551750||HBV Genotype + Drug Resistance||551559||**TEB [Telbivudine, Tyzeka]||56792-5|
|551750||HBV Genotype + Drug Resistance||551562||**ETV [Entecavir, Baraclude]||56791-7|
|551750||HBV Genotype + Drug Resistance||551563||**TNF [Tenofovir, Viread]||41396-3|