Hepatitis B Virus (HBV) Genotyping Plus Drug Resistance

CPT: 87900; 87912
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Test Details


  • HBV Genotype, PreCore and Resistance
  • HBV Resistance Testing


Data generated in the genotyping assay is subsequently analyzed for mutations in the reverse transcriptase gene of HBV associated with resistance to therapeutic agents, and if identified an interpretation of their clinical significance provided.


This assay may not be successful when the HBV viral load is <500 IU/mL.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.


Polymerase chain reaction (PCR) amplification and DNA sequencing

Specimen Requirements


Plasma or serum, frozen


1.2 mL

Minimum Volume

600 μL


Gel-barrier tube, yellow-top (ACD) tube, lavender-top (EDTA) tube or PPT.


Centrifuge sample within six hours of collection, transfer plasma/serum to a polypropylene screw-cap tube and freeze. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Causes for Rejection

Quantity not sufficient for analysis; heparin/SPS plasma (wrong anticoagulant); gross hemolysis; specimen not frozen


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
551750 HBV Genotype + Drug Resistance 551535 **HBV Genotype 32366-7
551750 HBV Genotype + Drug Resistance 551536 **HBV PreCore Mutation 54210-0
551750 HBV Genotype + Drug Resistance 551537 **HBV Drug Resistance Mutation 43279-9
551750 HBV Genotype + Drug Resistance 551538 **3TC [Lamivudine, Epivir] 30283-6
551750 HBV Genotype + Drug Resistance 551539 **ADV [Adefovir, Hepsera] 30288-5
551750 HBV Genotype + Drug Resistance 551559 **TEB [Telbivudine, Tyzeka] 56792-5
551750 HBV Genotype + Drug Resistance 551562 **ETV [Entecavir, Baraclude] 56791-7
551750 HBV Genotype + Drug Resistance 551563 **TNF [Tenofovir, Viread] 41396-3

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