Hepatitis B Virus (HBV) Genotype

CPT: 87912
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Test Details


  • HBV PreCore Mutations
  • HBV Subtype


The HBV genotype assay classifies the virus present in the sample into one of eight recognized genotypes (A-H) via sequence analysis of the DNA polymerase gene. Disease progression and response to therapy may be influenced by genotype. In addition, the HBV genotype assay identifies and reports sequence polymorphisms in the basal core promotor (BCP) and coding regions of the HBV precore gene that result in either decreased levels, or complete absence, of HBeAg expression in chronically infected patients.


This assay may not be successful when the HBV viral load is <500 IU/mL.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.


Polymerase chain reaction (PCR) amplification and DNA sequencing

Specimen Requirements


Plasma or serum, frozen


1.2 mL

Minimum Volume

600 μL


Gel-barrier tube, yellow-top (ACD) tube, lavender-top (EDTA) tube or PPT.


Centrifuge sample within six hours of collection, transfer plasma/serum to a polypropylene screw-cap tube and freeze. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Causes for Rejection

Quantity not sufficient for analysis; heparin/SPS plasma (wrong anticoagulant); gross hemolysis; specimen not frozen


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
551710 HBV Genotype 551578 HBV Genotype 32366-7
551710 HBV Genotype 551709 HBV Genotype/PreCore N/A
551710 HBV Genotype 551714 HBV PreCore Mutation 54210-0

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