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- Anti-HBc, IgM
- Antibody to Hepatitis B Core Antigen, IgM
IgM antibody to hepatitis B core antigen is a reliable marker for acute disease for a hepatitis B viral infection. At times this marker is the only one demonstrated for the diagnosis of a hepatitis B viral infection.
Immunochemiluminometric assay (ICMA)
Anti-HBc appears 5 to 14 days after HBe antigen and can be found shortly before HBsAg is no longer detectable. It may be negative in 9% of patients with acute hepatitis B in the first two weeks of illness, and should be repeated if clinically warranted. Anti-HBc and anti-HBe may be the only markers detectable in some patients at the time of presentation. The period between the disappearance of HBsAg and the appearance of HBsAb is often called the “core window.” Anti-HBc persists for months to years after resolution of acute hepatitis B, and also persists in cases of chronic infection; however, the demonstration of IgM-specific HBcAb is evidence that the patient is in an acute infection. Conversely, the absence of IgM core antibody in a patient with long-term B surface antigenemia suggests chronic hepatitis B viral infection. In addition, the absence of IgM core antibody with persistent B surface antigen and symptoms of acute hepatitis suggests acute non-A, non-B hepatitis or superinfection with δ hepatitis. See figure.
Serum or plasma
0.4 mL (Note: This volume does not allow for repeat testing.)
If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.
Causes for Rejection
Non-EDTA plasma specimen; PST gel-barrier tubes
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|016881||Hep B Core Ab, IgM||24113-3||016881||Hep B Core Ab, IgM||24113-3|