Helicobacter pylori Antibodies, IgA, IgG, IgM

CPT: 86677(x3)
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Test Details


  • Anti-Campylobacter Antibodies
  • Anti-H pylori Antibodies


Aid in the diagnosis of acute and chronic H pylori infections in patients with gastric and duodenal disease. Current studies suggest that H pylori IgM testing should be performed concomitantly with H pylori IgA and/or IgG tests for accurate diagnosis of Helicobacter pylori infection.


This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). Results of this test are for investigational purposes only. The results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically diagnostic product or procedure.


H pylori IgA and IgM: enzyme-linked immunosorbent assay (ELISA); H pylori IgG: chemiluminescence

Reference Interval

See individual tests.

Additional Information

Circulating antibodies to H pylori are predominantly of the IgG class. A systemic response of the IgA type is usually less pronounced but if significant, may indicate an early infection. Antibodies to IgG are the most useful for monitoring treatment.

Specimen Requirements




2 mL

Minimum Volume

1 mL


Red-top tube or gel-barrier tube

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

3 days


3 days


7 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Heat inactivated serum; hemolysis; lipemia; gross bacterial contamination

Clinical Information


Kosunen TU, Seppälä K, Sarna S, Sipponen P. Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori.Lancet. 1992 Apr 11; 339(8798):893-895. 1348298
Thomson ABR. Helicobacter pylori and gastroduodenal pathology. Can J Gastroenterol. 1993; 7(4):353-358.
von Wulffen H. An assessment of serological tests for the detection of Helicobacter pylori.Eur J Clin Microbiol Infect Dis. 1992 Jul; 11(7):577-582.1396763


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163683 H pylori, IgM, IgG, IgA Ab 162314 H. pylori, IgG Abs Index Value 5176-3
163683 H pylori, IgM, IgG, IgA Ab 163173 H. pylori, IgA Abs units 7901-2
163683 H pylori, IgM, IgG, IgA Ab 163208 H pylori, IgM Abs units 7903-8

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