Disopyramide, Serum or Plasma

CPT: 80299
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Test Details

Synonyms

  • Norpace®

Use

Evaluate toxicity; monitor therapeutic levels

Methodology

Immunoassay (IA)

Reference Interval

Therapeutic: 2.0−5.0 μg/mL

Critical Value

Potentially toxic: >5.0 μg/mL

Additional Information

Disopyramide shares electrophysiologic properties with quinidine and procainamide. Up to 80% of oral dose is absorbed. Half-life is 4 to 10 hours. Eighty percent of the drug is excreted in the urine. Dosage must be modified (dosage intervals prolonged) in patients with renal failure. Serious toxic effects are depression of myocardial contractility and disturbances in myocardial conduction. Other effects include dry mouth, constipation, urinary hesitancy, and blurred vision. Metabolite N-desisopropyl disopyramide is also pharmacologically active. Concomitant treatment with phenytoin may lead to decreased serum levels of disopyramide. There may be cumulative effect with other Class I antiarrhythmic drugs (lidocaine, procainamide).

Specimen Requirements

Specimen

Serum or plasma

Volume

1 mL

Minimum Volume

0.3 mL

Container

Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Collection

Transfer separated serum or plasma to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gel-barrier tube; hemolysis; lipemia; icteric specimen

Clinical Information

References

American Medical Association, Division of Drugs and Toxicology. Drug Evaluations Subscription. Chicago, Ill: AMA; Winter 1993.
Jürgens G, Graudal NA, Kampmann JP. Therapeutic monitoring of antiarrhythmic drugs. Clin Pharmacokinet. 2003; 42(7):647-663. 12844326

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
007864 Disopyramide, Serum 3576-6 007865 Disopyramide, Serum ug/mL 3576-6
Reflex Table for Disopyramide, Serum
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 007000 See below: 007000 See below: N/A

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