11-Deoxycortisol, LC/MS-MS (Endocrine Sciences)

CPT: 82634
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Test Details


  • 11-Deoxycortisol
  • Compound S


Evaluate hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve. 11-Deoxycortisol is the immediate precursor of cortisol and follows the same catabolic pathways as cortisol.


Liquid chromatography/tandem mass spectrometry (LC/MS-MS) after chromatography and solvent extraction

Reference Interval

See table.

Premature Infants

26 to 28 wk, day 4

110−1376 ng/dL

31 to 35 wk, day 4

48−579 ng/dL

Full-term Infants

3 d

13−147 ng/dL

31 d to 11 m

<10−156 ng/dL

Prepubertal Children

8 AM

20−155 ng/dL

Pubertal Children and Adults

8 AM

12−158 ng/dL

Additional Information

A primary use of 11-desoxycortisol testing is to detect congenital adrenal hyperplasia due to steroid 11-β-hydroxylase deficiency. This is a genetic disease caused by a deficiency of the CYP11B1 gene. 11-β-hydroxylase deficiency is transmitted as an autosomal recessive trait. It is associated with low-renin hypertension, hypokalemia, excess androgens (especially androstenedione), and genital ambiguity in affected females. The differential biochemical diagnosis of congenital adrenal hyperplasia caused by 11-β-hydroxylase deficiency includes finding increased serum concentrations of deoxycorticosterone, 11-desoxycortisol and androstenedione, and suppressed plasma renin concentrations. The disorder may be treated by administration of glucocorticoids. An additional use is to evaluate hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve. 11-deoxycortisol is the immediate precursor of cortisol and follows the same catabolic pathways as cortisol.

Specimen Requirements


Serum (preferred) or plasma


1 mL

Minimum Volume

0.2 mL


Gel-barrier tube, lavender-top (EDTA) tube, or green-top (heparin) tube


Serum/plasma must be separated from cells within 45 minutes of venipuncture. Send serum/plasma in a plastic transport tube.

Storage Instructions


Stability Requirements



Room temperature

1 day


1 day


2 years

Freeze/thaw cycles

Stable x3

Clinical Information

Special Instructions

For information on metyrapone testing, consult the Metyrapone Stimulation section of the Endocrine Appendix.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
500171 11-Desoxycortisol 504584 11-Desoxycortisol ng/dL 1657-6

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