Cytochrome P450 3A4/3A5 Genotyping

CPT: 81230; 81231
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Expected Turnaround Time

7 - 10 days


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Specimen Requirements


Specimen

Whole blood or LabCorp buccal swab kit (The buccal swab collection kit contains instructions for the use of a buccal swab.)


Volume

7 mL whole blood or LabCorp buccal swab kit


Minimum Volume

3 mL whole blood or two buccal swabs


Container

Lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab kit


Storage Instructions

Maintain specimen at room temperature, or refrigerate at 4°C.


Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; single buccal swab


Test Details


Use

This test provides genotypes for CYP3A4 and CYP3A5.


Limitations

This assay detects CYP3A4 alleles *1 and *22, and CYP3A5 alleles *1, *3, *6, *7. Other alleles are not detected by this assay.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Multiplex polymerase chain reaction (PCR) and primer extension


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504155 Cytochrome P450 3A4/3A5 81642-1 504161 3A4 Genotype: 81139-8
504155 Cytochrome P450 3A4/3A5 81642-1 504163 3A5 Genotype: 81140-6
504155 Cytochrome P450 3A4/3A5 81642-1 504633 Director Review: 72486-4
504155 Cytochrome P450 3A4/3A5 81642-1 504167 CYP3A4/3A5 Information: 62364-5
504155 Cytochrome P450 3A4/3A5 81642-1 000000 MGRM Informed Consent Review N/A

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf