Cytochrome P450 2C9 Genotyping

CPT: 81227
Updated on 9/9/2019
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Expected Turnaround Time

6 - 10 days


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Specimen Requirements


Specimen

Whole blood or LabCorp buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)


Volume

7 mL whole blood or LabCorp buccal swab kit


Minimum Volume

3 mL whole blood or two buccal swabs


Container

Lavender-top (EDTA) tube or yellow-top (ACD) tube or LabCorp buccal swab kit


Storage Instructions

Room temperature


Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; one buccal swab; wet buccal swab


Test Details


Use

This test provides genotype information for CYP2C9.

CYP2C9 is gene 9 within the C subfamily within the 2 family of the CYP450 superfamily. It metabolizes 5% of all prescribed drugs, such as glipizide, phenytoin, and warfarin. Genetic polymorphisms of CYP2C9 could be used to predict the altered enzyme activity and address the potential effects of metabolized drugs. Individuals exhibiting the most common variant alleles of 2C9, *2 or *3 are at increased risk of metabolizing a drug poorly or not at all. Deficient activity of 2C9 may result in reduced or lacking therapeutic benefit and an adverse drug reaction due to metabolite buildup in the body. This should be considered prior to initiating or modifying treatment or supplementing with additional drugs.

This test provides genotype information for CYP2C9.


Limitations

This assay detects CYP2C9 alleles *1, *2 and *3. Other alleles are not detected by this assay.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

The metabolism of drugs is also influenced by ethnicity, diet, and other medications. All factors should be considered prior to initiating new therapy.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

This assay detects CYP2C9 alleles *1, *2 and *3. Other alleles are not detected by this assay.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Real-time polymerase chain reaction (RT-PCR)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511893 Cytochrome P450 2C9 Genotyping 511890 2C9 Genotype 46724-1
511893 Cytochrome P450 2C9 Genotyping 511891 Comment: 77202-0
511893 Cytochrome P450 2C9 Genotyping 511892 Director Review: 72486-4
511893 Cytochrome P450 2C9 Genotyping 000000 MGRM Informed Consent Review N/A

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