Coma/Overdose Profile, Serum and Whole Blood

CPT: 80184; 80185; 80299; 80320; 80329; 80337; 80342; 80345; 80346
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Test Details

Test Includes

Acetaminophen; acetone; amitriptyline; butalbital; chlordiazepoxide; desipramine; diazepam; doxepin; ethanol; imipramine; isopropanol; meprobamate; methanol; norchlordiazepoxide; nordiazepam; nordoxepin; nortriptyline; pentobarbital; phenobarbital; phenytoin; salicylates

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS), gas chromatography, spectrophotometry, and immunoassay

Specimen Requirements

Specimen

Serum and whole blood

Volume

4 mL serum and 7 mL whole blood

Minimum Volume

1.5 mL serum and 0.5 mL whole blood

Container

Red-top tube and gray-top (sodium fluoride) tube

Collection

Separate serum from cells and transfer to a plastic transport tube. Submit full, unopened gray-top tube for analysis of volatiles. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Storage Instructions

Refrigerate.

Causes for Rejection

Gel tube; hemolysis; gross lipemia; icteric specimen

Clinical Information

Special Instructions

Sample is tested for the presence of the substances listed above (see Test Includes). Drugs will be quantitated; please indicate suspected substance, if possible.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
007022 Serum Coma Overdose Profile 007066 Acetone % 5568-1
007022 Serum Coma Overdose Profile 007063 Ethanol % 56478-1
007022 Serum Coma Overdose Profile 007064 Isopropanol % 5669-7
007022 Serum Coma Overdose Profile 007065 Methanol % 5693-7
007022 Serum Coma Overdose Profile 720228 Acetaminophen ug/mL 3298-7
007022 Serum Coma Overdose Profile 017194 Pentobarbital ug/mL 3924-8
007022 Serum Coma Overdose Profile 017210 Phenobarbital ug/mL 3948-7
007022 Serum Coma Overdose Profile 072181 Butalbital ug/mL 6895-7
007022 Serum Coma Overdose Profile 716035 Chlordiazepoxide ug/mL 3457-9
007022 Serum Coma Overdose Profile 716043 Norchlordiazepoxide ug/mL 9776-6
007022 Serum Coma Overdose Profile 716050 Nordiazepam ug/mL 3537-8
007022 Serum Coma Overdose Profile 716068 Diazepam ug/mL 3548-5
007022 Serum Coma Overdose Profile 700021 Phenytoin ug/mL 3968-5
007022 Serum Coma Overdose Profile 700013 Salicylates ug/mL 4024-6
007022 Serum Coma Overdose Profile 072413 Amitriptyline ng/mL 3333-2
007022 Serum Coma Overdose Profile 700088 Nortriptyline ng/mL 3872-9
007022 Serum Coma Overdose Profile 072439 Imipramine ng/mL 3690-5
007022 Serum Coma Overdose Profile 700104 Desipramine ng/mL 3531-1
007022 Serum Coma Overdose Profile 072421 Doxepin ng/mL 3579-0
007022 Serum Coma Overdose Profile 700096 Nordoxepin ng/mL 3862-0
Reflex Table for Butalbital
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 700473 Disclaimer: 700473 Disclaimer: N/A

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf