c-MET Oncology FISH

CPT: Contact CPT coding department at 800-222-7566, ext 6-8400. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Details

Synonyms

  • Adenocarcinoma
  • Non−Small-cell Lung Cancer

Use

Confirmation/identification of cancer-related alterations (for lung cancer).

Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Specimen

FNA, formalin-fixed paraffin blocks are also acceptable.

Volume

Five slides (4- to 5-micron thick sections)

Minimum Volume

Two slides (4- to 5-micron thick sections)

Container

Paraffin block

Collection

Transport to the test facility at room temperature.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; absence of tumor or quantity not sufficient for analysis

Clinical Information

References

Lennerz JK, Kwak EL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011 Dec 20; 29(36):4803-4810. 22042947

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510890 C-MET Oncology FISH 510834 Specimen Type 31208-2
510890 C-MET Oncology FISH 510835 Cells Counted 62361-1
510890 C-MET Oncology FISH 510836 Cells Analyzed 62360-3
510890 C-MET Oncology FISH 510837 FISH Result 48674-6
510890 C-MET Oncology FISH 510838 Interpretation 62365-2
510890 C-MET Oncology FISH 510839 Director Review: 48672-0
Reflex Table for Interpretation
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511597 Comment: 511597 Comment: N/A

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