Citric Acid (Citrate), Random Urine

CPT: 82507
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Synonyms

  • Citrate Excretion, Urine

Special Instructions

pH must be 1 to 3 or the sample frozen without the addition of acid.


Expected Turnaround Time

3 - 5 days


Related Documents


Specimen Requirements


Specimen

Urine (random), acidified or frozen


Volume

2 mL


Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)


Container

Use random urine transport tube or urine Monovette® with pH stabilizer (Labcorp No. 56015). Monovette® instructions accompany units.


Collection

Collect urine and transfer to a random urine transport tube or urine Monovette® with pH stabilizer (Labcorp No. 56015). Alternatively, the sample may be frozen without added acid.


Storage Instructions

Refrigerate at 2°C to 8°C.


Stability Requirements

Temperature

Period

Room temperature

29 days

Refrigerated

29 days

Frozen

49 days

Freeze/thaw cycles

Stable x5


Causes for Rejection

Citrate: Boric Acid used as a preservative (Boric acid ≥1250 mg/dL may cause citrate results to be reduced by approximately 30%); multivitamin ≥397.5 mg/dL (estimated as 1 pill per day) may cause citrate results to be unmeasurable. Results of interference testing may not be representative of in-vivo characteristics of multivitamin consumption.


Test Details


Use

A timed 24-hour urine collection is the preferred specimen for measuring and interpreting this urinary analyte. Random collections normalized to urinary creatinine may be of some clinical use in patients who cannot collect a 24-hour specimen, typically small children. The mean urinary citrate excretion rate in patients with idiopathic calcium urolithiasis has been found to be significantly lower than that of control groups. Hypocitraturia is common in patients with urolithiasis resulting from renal tubular acidosis and in patients with enteric hyperoxaluria. Citrate excretion is low in renal insufficiency.


Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Nuclear magnetic resonance (NMR) or Enzymatic


Reference Interval

See table.

Gender

Age (y)

Range (mg/L)

Male

<40

9−864

≥40

7−1130

Female

<40

40−1930

≥40

10−1560


References

Tietz NW. Clinical Guide to Laboratory Tests. 4th ed. Philadelphia, Pa: WB Saunders Co; 2006.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123866 Citric Acid(Citrate), Random U 2128-7 016869 Citric Acid, Random Urine mg/L 2128-7

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