Chronic Lymphocytic Leukemia (CLL) Profile, FISH

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Synonyms

  • Chronic Lymphocytic Leukemia

Test Includes

Fluorescence in situ hybridization (FISH) for chronic lymphocytic leukemia (CLL) and leukemic phase of mantle cell lymphoma (ATM, 12, 13q, 17p, and CCND1/IgH fusion)


Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetic studies on the request form.


Expected Turnaround Time

3 - 5 days



Related Documents


Specimen Requirements


Specimen

Blood, bone marrow, fixed-cell pellet from a cytogenetic analysis, or slides prepared from a cytogenetic analysis


Volume

10 mL blood (adult), 3 to 5 mL blood (pediatric), 1 to 3 mL bone marrow, one tube fixed-cell pellet, or four slides


Minimum Volume

1 mL blood (adult/pediatric), 1 mL bone marrow, or three slides


Container

Green-top (sodium heparin) tube, pediatric Vacutainer® is optimal; or lavender-top (EDTA) tube


Storage Instructions

Maintain specimen at room temperature.


Causes for Rejection

Broken Vacutainer®; broken slides


Test Details


Use

Diagnostic and prognostic test for chronic lymphocytic leukemia; detection rate is improved from 45% with a chromosome study to 80% with fluorescence in situ hybridization (FISH). Differentiates CLL from MCL.


Limitations

Molecular mutations below the resolution of FISH will not be detected.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.


Methodology

Fluorescence in situ hybridization (FISH)


References

Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000 Dec 28; 343(26):1910-1916.11136261

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510340 CLL FISH Panel 510709 Specimen Type 31208-2
510340 CLL FISH Panel 510687 Cells Counted 62361-1
510340 CLL FISH Panel 510688 Cells Analyzed 62360-3
510340 CLL FISH Panel 510689 FISH Result 48674-6
510340 CLL FISH Panel 510337 Interpretation 50398-7
510340 CLL FISH Panel 510338 Director Review: 48672-0
510340 CLL FISH Panel 512123 PDF 51967-8

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