Chimerism Analysis With CD3 Cells (Transplant Monitoring)

CPT: 81268
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Test Details

Synonyms

  • Cell Sorting CD3
  • Chimerism Analysis With Sorted Lymphoid Cells
  • Engraftment Monitoring Sorted Lymphoid Cells

Use

Monitor the level of donor CD3+ cells in the recipient (patient-host) of a stem cell transplant. Polymorphic loci determined in the preëngraftment testing are used as a reference for the evaluation.

Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Methodology

Antibody-mediated positive selection of CD3+ cells and separation with magnetic nanoparticles. DNA analysis by polymerase chain reaction (PCR) of short tandem repeats (STR)

Specimen Requirements

Specimen

Whole blood

Volume

6 mL

Minimum Volume

2 mL

Container

Yellow-top (ACD-A or ACD-B) tube

Patient Preparation

None

Storage Instructions

Maintain specimen at room temperature. Do not refrigerate or freeze. Ship specimen to arrive in the laboratory between Monday and Friday.

Causes for Rejection

Improper collection tube (ie, EDTA or heparin); hemolysis; clotted specimen

Clinical Information

Special Instructions

To schedule this test, you must telephone 800-533-1037, HLA customer service.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
176059 Chimerism Analysis CD3 Cells 176129 Donor 1 N/A
176059 Chimerism Analysis CD3 Cells 176231 Donor 2 N/A
176059 Chimerism Analysis CD3 Cells 176232 Donor 3 N/A
176059 Chimerism Analysis CD3 Cells 176233 Donor 4 N/A

For Providers

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf