Chain-of-Custody Protocol, Specimen

CPT: 99199
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Test Details


  • Specimen Chain-of-Custody Protocol


Chain-of-custody is a legal protocol describing the documentation of specimen transfer from the time of collection until final disposition.

Additional Information

The chain-of-custody protocol is a clerical and custodial service offered by the laboratory to document specimen transfer and provide for extended specimen storage. A written record of specimen transfer, from patient, to analyst, to storage and disposal, is maintained on all specimens covered by chain-of-custody. All drug tests, blood alcohol, or any other tests that have medicolegal significance should be accompanied by a chain-of-custody.

Specimen Requirements

Causes for Rejection

Quantity not sufficient for analysis; improper specimen (serum, plasma, blood); incomplete chain-of-custody documentation; incomplete specimen identification; improper or missing tamper-evident seals

Clinical Information


Smith ML, Bronner WE, Shimomura ET, Levine BS, Froede RC. Quality assurance in drug testing laboratories. Clin Lab Med. 1990 Sep; 10(3):503-516. 2253447


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070466 Chain-of-Custody Protocol N/A 070466 Chain-of-Custody Protocol N/A

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