Buprenorphine and Metabolite

CPT: 80348
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Test Details


  • Buprenex®
  • Free Buprenorphine
  • Subutex®


Buprenorphine is used in the management of moderate to severe chronic pain.

Half-life elimination: IV: 2.2 to 3 hours, Sublingual tablet: approximately 37 hours, Transdermal patch: approximately 26 hours

Time to peak plasma: Sublingual: 30 minutes to 1 hour


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Specimen Requirements


Serum, plasma, or whole blood


0.25 mL

Minimum Volume

0.1 mL


Red-top tube, lavender-top (EDTA) tube, gray-top (sodium fluoride) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.


Separate serum or plasma within two hours of collection and transfer to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Causes for Rejection

Gel-barrier tube

Clinical Information


Drug Information Handbook. 24th ed. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2015; 300-304.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070103 Buprenorphine and Metabolite 070101 Buprenorphine ng/mL 3413-2
070103 Buprenorphine and Metabolite 070102 Norbuprenorphine ng/mL 53881-9

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