Buprenorphine and Metabolite

CPT: 80348
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Test Details

Synonyms

  • Buprenex®
  • Free Buprenorphine
  • Subutex®

Use

Buprenorphine is used in the management of moderate to severe chronic pain.

Half-life elimination: IV: 2.2 to 3 hours, Sublingual tablet: approximately 37 hours, Transdermal patch: approximately 26 hours

Time to peak plasma: Sublingual: 30 minutes to 1 hour

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Specimen Requirements

Specimen

Serum, plasma, or whole blood

Volume

0.25 mL

Minimum Volume

0.1 mL

Container

Red-top tube, lavender-top (EDTA) tube, gray-top (sodium fluoride) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Collection

Separate serum or plasma within two hours of collection and transfer to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Causes for Rejection

Gel-barrier tube

Clinical Information

References

Drug Information Handbook. 24th ed. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2015; 300-304.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070103 Buprenorphine and Metabolite 070101 Buprenorphine ng/mL 3413-2
070103 Buprenorphine and Metabolite 070102 Norbuprenorphine ng/mL 53881-9

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