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- ABL1 Mutation Analysis for Resistance to Imatinib Mesylate
- Gleevec Resistance Mutation Analysis
- Imatinib Mesylate Resistance Analysis
Mutations within the BCR-ABL1 kinase domain in imatinib-treated chronic myeloid leukemia are the main mechanism of acquired resistance. The early detection of mutations should provide clinical benefit by allowing early intervention. Candidates for the BCR-ABL1 kinase domain mutation analysis include:
• Patients who fail to respond to imatinib therapy
• Patients with significant increase in BCR-ABL1 levels as detected by the quantitative BCR-ABL1 assay
• Patients with a loss of cytogenetic or hematologic response
• Patients in accelerated phase/blast crisis
In vitro studies indicate that this analysis has a mutation detection sensitivity of ∼20%. Mutations occurring outside of the analyzed region of the ABL kinase domain will also not be detected by this assay.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Polymerase chain reaction (PCR); direct sequencing; capillary electrophoresis
Whole blood or bone marrow
3 to 7 mL whole blood or 1 to 2 mL bone marrow
3 mL whole blood or 1 mL bone marrow
Lavender-top (EDTA) tube, green-top (sodium heparin) or yellow-top (ACD-A) tube
Submit at room temperature. Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on request form.
Ship at room temperature. If specimen must be stored prior to shipment, store at 2°C to 8°C.
Causes for Rejection
Specimen does not meet all of the above criteria for sample type, container, minimum volume, collection and storage; unsuitable specimens include but are not limited to: frozen whole blood or marrow; a leaking tube; clotted blood or marrow; a grossly hemolyzed specimen or otherwise visibly degraded; specimen suspected of being contaminated by another specimen; specimen contains specific foreign material
Please direct any questions regarding this test to oncology customer service at 800-345-4363.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|480510||BCR-ABL1 kinase domain||480511||Result:||55135-8|
|480510||BCR-ABL1 kinase domain||480512||Nucleotide Change:||48004-6|
|480510||BCR-ABL1 kinase domain||480513||Predicted Amino Acid Change:||48005-3|
|480510||BCR-ABL1 kinase domain||480843||Interpretation:||50398-7|
|480510||BCR-ABL1 kinase domain||480844||Methodology:||49549-9|
|480510||BCR-ABL1 kinase domain||481526||Disclaimer:||N/A|
|480510||BCR-ABL1 kinase domain||480515||Director Review:||72486-4|