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B-Cell Gene Rearrangements Profile, IgH and IgK
- IgH Clonality Assay
- IgH Gene Rearrangement Assay
- IgK Clonality Assay
- IgK Gene Rearrangement Assay
This profile can be used to detect clonal B-cell immunoglobulin heavy chain (IgH) and immunoglobulin κ light chain (IgK) gene rearrangements in blood, bone marrow, and tissue specimens with combined B-cell clonality detection rate of 99%. The presence of a monoclonal gene rearrangement usually, but not always, reflects the presence of a B-lymphocytic neoplasm, while polyclonal gene rearrangement patterns are found in benign reactive condition. Thus, the results of these studies can assist in the diagnosis of lymphoproliferative disorders.
This PCR assay is able to detect a clonal DNA population at the sensitivity of 5% in a background of polyclonal DNA.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Polymerase chain reaction (PCR)
Whole blood, bone marrow, formalin-fixed, paraffin-embedded (FFPE) tissue block or slides, fresh or frozen tissue
3 to 5 mL whole blood, 1 mL bone marrow, five unstained slides at 10 μM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen
0.5 mL whole blood, 0.5 mL bone marrow, two unstained slides at 10 μM
Lavender-top (EDTA) tube, yellow-top (ACD) tube, green-top (heparin) tube, FFPE tissue block or slides, or tissue in RPMI or frozen
Fresh tissue should be placed in RPMI medium or shipped frozen on dry ice. Small samples (eg, punch biopsies, fine-needle aspirates) will also be accepted. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate specimens for each test requested.
Maintain blood, bone marrow or tissue in RPMI at 2°C to 8°C; FFPE specimens at room temperature; tissue at -80°C.
Causes for Rejection
Frozen whole blood/bone marrow; quantity not sufficient for analysis; tumor tissue; broken or stained slides
Please direct any questions regarding this test to customer service at 800-345-4363.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|481222||B Cell Panel (IgH, IgK)||480717||B-Cell PCR Interpretation||21747-1|
|481222||B Cell Panel (IgH, IgK)||480827||B Clonal Size||N/A|
|481222||B Cell Panel (IgH, IgK)||480778||Block Number:||N/A|
|481222||B Cell Panel (IgH, IgK)||489025||Director Review:||72486-4|
|481222||B Cell Panel (IgH, IgK)||480720||Methodology:||49549-9|
|481222||B Cell Panel (IgH, IgK)||481529||References:||N/A|
|481222||B Cell Panel (IgH, IgK)||480813||IgK PCR Interpretation||21748-9|
|481222||B Cell Panel (IgH, IgK)||480828||K Clonal Size||N/A|
|481222||B Cell Panel (IgH, IgK)||480777||Block Number:||N/A|
|481222||B Cell Panel (IgH, IgK)||489028||Director Review||72486-4|
|481222||B Cell Panel (IgH, IgK)||480831||Methodology:||49549-9|
|481222||B Cell Panel (IgH, IgK)||480842||References:||N/A|