Bacterial Vaginosis, Sialidase Activity

CPT: 87905
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Test Details

Synonyms

  • BV (Sialidase) Activity
  • Vaginitis
  • Vaginosis

Use

Enzyme activity test for use in the detection of vaginal fluid specimens for sialidase activity, an enzyme produced by bacteria associated with bacterial vaginitis, including Bacteroides spp, Prevotella spp, and Mobiluncus spp and some G vaginalis. In a recent study, Bradshaw et al demonstrated the test to be 88% sensitive and 95% specific.

Limitations

Collecting specimens from the cervix should be avoided because (a) it might increase risk to OB patients, and (b) cervical sialidase activity is usually higher than vaginal sialidase activity. Do not collect specimens from patients who have (a) used a vaginal cream or ointment product, (b) douched, or (c) used spermicides, vaginal lubricants, or feminine sprays within 72 hours of testing. If insufficient sample is collected or collected from a patient undergoing antimicrobial therapy, the test may give a false-negative result.

Methodology

Chromogenic enzyme activity test

Specimen Requirements

Specimen

Vaginal fluid

Volume

Swab

Container

Copan double swab in Amies liquid medium

Collection

Using transport swabs provided, obtain a sample by contacting the lower one-third of the vaginal wall, rotating 10 to 20 seconds to absorb fluid. Immediately place the swabs into the transport tube.

Storage Instructions

Maintain specimen at room temperature for up to 48 hours.

Causes for Rejection

Specimen collected or transported other than previously described

Clinical Information

References

Bradshaw CS, Morton AN, Garland SM, Horvath LV, Kuzevska I, Fairley CK. Evaluation of a point-of-care test, BVBlue, and clinical laboratory criteria for diagnosis of bacterial vaginosis. J Clin Microbiol. 2005 Mar; 43(3):1304-1308. 15750100

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
180034 BV, Sialidase Activity 41477-1 180035 BV, Sialidase Activity 41477-1

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