Antiphospholipid Syndrome (APS), Comprehensive (Consultative)

CPT: 85597; 85598; 85613(x2); 85730; 85732(x2); 86146(x3); 86147(x3); 86148(x2); 86849
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Test Details

Test Includes

Activated partial thromboplastin time (aPTT); aPTT 1:1 NP; aPTT 1:1 saline; anticardiolipin antibody, IgA, IgG, IgM; antiphosphatidylserine, IgG, IgM; antiprothrombin antibody, IgG; β2-glycoprotein 1, IgA, IgG, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; hexagonal phospholipid neutralization; lupus anticoagulant interpretation; platelet neutralization

Use

Determine the presence of antiphospholipid antibodies, using either clot-based or ELISA technology, that may be associated with an increased risk for arterial or venous thrombosis or obstetric complications. These antibodies may also be the cause of an elevated activated partial thromboplastin time (aPTT).

Methodology

See individual tests.

Specimen Requirements

Specimen

Serum and plasma, frozen

Volume

Three 2 mL each frozen citrated plasma tubes and one 1 mL tube frozen serum

Container

Blue-top (sodium citrate) tubes and red-top tube or gel-barrier tube

Collection

Serum/plasma must be separated from cells within 45 minutes of venipuncture. Send serum/plasma in plastic transport tubes. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze.

Causes for Rejection

Wrong sample type; fibrin clot in plasma sample

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504400 Antiphospholipid Syndrome Comp 500513 APTT sec 14979-9
504400 Antiphospholipid Syndrome Comp 500363 APTT 1:1 NP sec 5946-9
504400 Antiphospholipid Syndrome Comp 500364 APTT 1:1 Saline Sec 43734-3
504400 Antiphospholipid Syndrome Comp 501549 DRVVT Screen Seconds sec 6303-2
504400 Antiphospholipid Syndrome Comp 501548 DRVVT Confirm Seconds sec 57838-5
504400 Antiphospholipid Syndrome Comp 500585 DRVVT Ratio ratio 50410-0
504400 Antiphospholipid Syndrome Comp 500569 Hexagonal Phospholipid Neutral sec 3282-1
504400 Antiphospholipid Syndrome Comp 500049 Platelet Neutralization sec 3284-7
504400 Antiphospholipid Syndrome Comp 500575 Anticardiolipin Ab, IgG GPL 3181-5
504400 Antiphospholipid Syndrome Comp 500571 Anticardiolipin Ab, IgM MPL 3182-3
504400 Antiphospholipid Syndrome Comp 500581 Anticardiolipin Ab, IgA APL 5076-5
504400 Antiphospholipid Syndrome Comp 500589 Beta-2 Glycoprotein I, IgG SGU 16135-6
504400 Antiphospholipid Syndrome Comp 500593 Beta-2 Glycoprotein I, IgM SMU 16136-4
504400 Antiphospholipid Syndrome Comp 500591 Beta-2 Glycoprotein I, IgA SAU 21108-6
504400 Antiphospholipid Syndrome Comp 500577 Antiphosphatidylserine IgG GPS 32032-5
504400 Antiphospholipid Syndrome Comp 500579 Antiphosphatidylserine IgM MPS 32033-3
504400 Antiphospholipid Syndrome Comp 500782 Antiprothrombin Antibody, IgG G units 40595-1
504400 Antiphospholipid Syndrome Comp 502038 LAC Interpretation 3281-3

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