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Amino Acid Profile, Glycine Encephalopathy, Plasma and Cerebrospinal Fluid
Diagnosis of glycine encephalopathy (nonketotic hyperglycinemia).
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Plasma, frozen and cerebrospinal fluid (CSF), frozen
0.5 mL plasma and 0.5 mL CSF
0.25 mL plasma and 0.25 mL CSF
Preferred: Frozen plasma from green-top (sodium heparin) tube and CSF: plastic transport tube, no preservative. Acceptable: Frozen plasma from green-top (lithium heparin) tube, frozen plasma from lavender-top (EDTA) tube or frozen plasma from PPT™. Frozen serum from serum separator tube (SST) or frozen serum from red-top tube will not be rejected. Note: Plasma reference ranges will be applied to all specimen types.
Plasma and CSF should be simultaneously collected (venipuncture immediately prior to lumbar puncture). Separate plasma from cells. Transfer specimen to plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Plasma: Centrifuge, remove plasma from cells, and freeze immediately, CSF: freeze immediately.
Causes for Rejection
Gross hemolysis; room temperature or thawed specimen; specimens collected in ACD (yellow-top) tubes
For plasma and cerebrospinal fluid collected more than 20 minutes, order Amino Acid Profile, Quantitative, Plasma (700068) or Amino Acid Profile, Quantitative, Cerebrospinal Fluid (700180). To discuss amino acid testing options, please call 1-800-345-GENE and ask to speak to a Biochemical Geneticist.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|700200||Amino Acids, Glycine, Pl + CSF||700508||Glycine Plasma||umol/L||20644-1|
|700200||Amino Acids, Glycine, Pl + CSF||700509||Glycine CSF||umol/L||22650-6|
|700200||Amino Acids, Glycine, Pl + CSF||700512||CSF:Plasma||73913-6|
|700200||Amino Acids, Glycine, Pl + CSF||700164||Interpretation||49303-1|
|700200||Amino Acids, Glycine, Pl + CSF||700166||Methodology||49549-9|
|700200||Amino Acids, Glycine, Pl + CSF||700471||Disclaimer:||N/A|