ALK FISH With Reflex to RET and ROS1

CPT: 88271(x2); 88274. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Details


  • FISH
  • Oncology FISH

Test Includes

A negative ALK FISH will reflex to RET and ROS1 FISH. Additional charges will be applied for the embedding process if formalin-fixed tissue is submitted.


Confirmation/identification of cancer-related alteration in non−small-cell lung cancer


Fluorescence in situ hybridization (FISH)

Specimen Requirements


Formalin-fixed paraffin-embedded (FFPE) tissue


Paraffin block

Storage Instructions

Maintain specimen at room temperature.

Clinical Information

Special Instructions

Pertinent clinical diagnosis should be included with the specimen.

For Providers

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at