ALK FISH, Non−Small-cell Lung Cancer

CPT: 88271(x2); 88274
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Test Details

Synonyms

  • NSCLC ALK FISH
  • Oncology FISH

Use

Confirmation/identification of non−small-cell lung cancer. This is an FDA-approved test for the identification of NSCLC patients who may be eligible for treatment.

Methodology

Fluorescence in situ hybridization (FISH) from formalin-fixed paraffin-embedded (FFPE) tissue (4-micron to 5-micron sections); H&E for pathology review

Specimen Requirements

Specimen

Formalin-fixed paraffin-embedded (FFPE) tissue

Volume

Five slides (4‐ to 5‐micron thick sections)

Minimum Volume

Two slides (4‐ to 5‐micron thick sections)

Container

Paraffin block

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Improper embedded prep; poor fixation <6 hours and >72 hours; decalcified bones or bone core; broken or dirty slides; absence of tumor or quantity not sufficient for analysis

Clinical Information

Special Instructions

Pertinent clinical diagnosis, including the pathology report documenting pulmonary origin, should be included with the specimen. Additional charges will be applied for the embedding process if formalin-fixed tissue is submitted.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510950 ALK FISH, Lung, Non-Small Cell 510510 Specimen Type 31208-2
510950 ALK FISH, Lung, Non-Small Cell 510511 Cells Counted 62361-1
510950 ALK FISH, Lung, Non-Small Cell 510512 Cells Analyzed 62360-3
510950 ALK FISH, Lung, Non-Small Cell 510948 FISH Result 48674-6
510950 ALK FISH, Lung, Non-Small Cell 510529 Interpretation 62365-2
510950 ALK FISH, Lung, Non-Small Cell 510949 Director Review: 48672-0
510950 ALK FISH, Lung, Non-Small Cell 510273 ALK FISH, Putaway N/A

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf