Abnormal PT/aPTT Reflexive Profile (Esoterix)

CPT: 80500; 85610; 85613(x2); 85670; 85730
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Test Details

Test Includes

Activated partial thromboplastin time (aPTT); dilute Russell's viper venom time (dRVVT); international normalized ratio (INR); pathologist interpretation; prothrombin time; thrombin time


See individual tests.

Specimen Requirements


Citrated plasma, frozen


Three 1 mL platelet-poor frozen tubes


Blue-top (sodium citrated) tubes

Patient Preparation

Ideally the patient should not be on anticoagulant therapy. Avoid warfarin (Coumadin®) therapy for two weeks prior to the test and heparin, direct Xa and thrombin inhibitor therapies for about three days prior to testing.


Plasma must be separated from cells within 45 minutes of venipuncture and centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Clinical Information

Special Instructions

• If PT is >3 seconds above the upper limit of normal, the test will reflex to PT mixing studies and factor VII activity.

• If aPTT is >5 seconds above the upper limit of normal, the test will reflex to aPTT mixing studies, hexagonal phospholipid neutralization, factor XI activity, factor IX activity, and factor VIII activity.

• If TT is abnormal, the test will reflex to fibrinogen activity and fibrinogen antigen.

• If reflex testing is performed, concomitant CPT codes/charges will apply.

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