Glomerulonephritis (GNP) Profile (RDL)

CPT: 83516(x3); 83520; 86036; 86160(x2); 86225
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Test Includes

This profile is composed of Anti-Nuclear Ab (ANA) by IFA, Anti-dsDNA Ab by Farr, Anti-Glomerular Basement Membrane Ab (GBM), Anti-Neutrophil Cytoplasmic Ab (ANCA), Anti-Myeloperoxidase Ab (MPO), Anti-Proteinase 3 Ab (PR-3), C3 Complement, C4 Complement.

ANA performed if ANCA positive to rule out false positive ANCA due to presence of ANA.


Expected Turnaround Time

10 - 12 days


Related Documents

For more information, please view the literature below.

Autoimmune Profiles Brochure


Specimen Requirements


Specimen

Serum


Volume

4 mL


Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Period

Room temperature

2 days

Refrigerated

8 days

Frozen

8 days


Test Details


Use

ANA are commonly present in a variety of autoimmune diseases. ANA frequency also increases with age in apparently healthy people. ANA patterns on HEp-2 slides provide general clues about particles (chromatin, nucleosomes, and spliceosomes).

The Farr assay is the most specific method for detecting dsDNA autoantibodies. Significant elevations in dsDNA autoantibody concentrations confirm the diagnosis of systemic lupus erythematosus (SLE). Serial studies of elevated values of dsDNA auto antibodies are useful for predicting activity of SLE.

Anti-MPO autoantibodies aid in assessment of certain autoimmune vasculitides such as microscopic polyarteritis, and crescentic glomerulonephritis.

Elevated levels of Anti-PR-3 antibodies are classically observed in patients with Wegener granulomatosis (WG), particularly with active disease, and less frequently in other forms of necrotizing vasculitis.

Anti-GBM autoantibodies are recognized as being important in the pathogenesis of the rapidly progressive glomerulonephritis of Goodpasture's syndrome. Measurements of C3 and C4 are used to detect individuals with inborn deficiency of this factor or those with immunologic disease in whom complement is consumed at an increased rate. These include lupus erythematosus, chronic active hepatitis, certain chronic infections, post-streptococcal and membranoproliferative glomerulonephritis, and others.


Methodology

See individual test components.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520194 Glomerulonephritis (GNP) Prof Pending 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
520194 Glomerulonephritis (GNP) Prof Pending 520150 ANCA by IFA (RDL) 29641-8
520194 Glomerulonephritis (GNP) Prof Pending 520211 Anti-MPO Ab (RDL) Units 46266-3
520194 Glomerulonephritis (GNP) Prof Pending 520215 Anti-PR-3 Ab (RDL) Units 46267-1
520194 Glomerulonephritis (GNP) Prof Pending 520249 Anti-GBM Ab (RDL) Units 31406-2
520194 Glomerulonephritis (GNP) Prof Pending 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
520194 Glomerulonephritis (GNP) Prof Pending 520169 C3 Complement (RDL) mg/dL 4485-9
520194 Glomerulonephritis (GNP) Prof Pending 520167 C4 Complement (RDL) mg/dL 4498-2
520194 Glomerulonephritis (GNP) Prof Pending 520260 Interpretation: N/A
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520074 Homogeneous Pattern 20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520076 Nucleolar Pattern 20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520233 Speckled Pattern 20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520234 Centromere Pattern 53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520235 Spindle Apparatus Pattern 53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520236 Nuclear Membrane Pattern 54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520237 Midbody Pattern 54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520238 Nuclear Dot Pattern 53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520239 PCNA Pattern 53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520240 Centriole Pattern 53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520241 Note: 77202-0
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520257 Positive ANCA Reflex 520187 C-ANCA (IFA-ETOH) 14277-8
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520257 Positive ANCA Reflex 520189 P-ANCA (IFA-ETOH) 14278-6
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520257 Positive ANCA Reflex 520191 P-ANCA (IFA-Formalin) 17357-5

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