Find Locations
For hours, walk-ins and appointments.Synonyms
- Centromere
Test Includes
This test is a component of ANA Profile 11, ANA 12 Profile, ANA 12 Plus Profile, Scleroderma Comprehensive Profile, Scleroderma Comprehensive Profile Plus.
Expected Turnaround Time
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Refrigerate or freeze.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Test Details
Use
The most common setting for finding anti-centromere antibodies is in patients with a limited cutaneous form of scleroderma. Anti-centromere abs are found in 22% of patients with systemic sclerosis and in 12% of patients with primary biliary cirrhosis, and are rarely present in normal individuals.
Methodology
Indirect fluorescent antibody (IFA)
Additional Information
Anti-centromere abs are found in 46% of patients with Limited Systemic Sclerosis and 11% in Diffuse Systemic Sclerosis, as well as 12% of patients with primary biliary cirrhosis, and are rarely present in normal individuals. The antibodies are associated with CREST syndrome.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520065 | Anti-Centromere Ab by IFA(RDL) | 5077-3 | 520066 | Anti-Centromere Ab by IFA(RDL) | 5077-3 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf