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CPT:
86200
Synonyms
- Anti-Cyclic Citrullinated Peptide Ab
- CCP
- Cyclic Citrullinated Peptide Antibody
Expected Turnaround Time
5 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Rheumatoid Arthritis Testing With Better Performance Brochure
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Refrigerate or freeze.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Test Details
Use
Anti-CCP (cyclic citrullinated peptide) antibodies are autoantibodies present in established rheumatoid arthritis (RA) (sensitivity 66-79%) and early RA (sensitivity 59%).1,2 In addition, Anti-CCP is more specific than RF diagnosis (specificity 90-96%).1,3
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Enzyme-linked immunosorbent assay (ELISA)
Footnotes
1. Lee DM, Schur PH. Clinical utility of the anti-CCP assay in patients with rheumatic diseases. Ann Rheum Dis. 2003 Sep;62(9):870-874.12922961
2. Maksymowych WP, Naides SJ, Bykerk V, et al. Serum 14-3-3 eta is a novel marker that complements current serological measurements to enhance detection of patient with rheumatoid arthritis. J Rheumatol. 2014 Nov;41(11):2104-2113.25128504
3. Dubucquoi S, Solau-Gervais E, Lefranc D, et al. Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases. Ann Rheum Dis. 2004 Apr;63(4):415-419.15020336
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520008 | Anti-CCP Ab, IgG + IgA (RDL) | 57093-7 | 520047 | Anti-CCP Ab, IgG + IgA (RDL) | Units | 57093-7 |
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