Killer Immunoglobulin-like Receptors (KIR)

CPT: 81403
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Synonyms

  • KIR
  • KIR Genotyping
  • KIR SSO Genotyping Test
  • KIR Typing

Special Instructions

If you have questions or for assistance in selecting the proper KIR test for the patient, please call HLA customer serivce at 800-533-1037 or email [email protected].


Expected Turnaround Time

3 - 9 days


Specimen Requirements


Specimen

Whole blood


Volume

7 mL


Minimum Volume

3 mL


Container

Lavender-top (EDTA) tube


Storage Instructions

Maintain specimen at room temperature.


Causes for Rejection

Highly lipemic or hemolyzed specimen


Test Details


Use

The function of natural killer cells in the immune response is regulated by killer immunoglobulin-like receptors (KIR). These receptors interact with class I HLA antigens on the cell surface to prevent or activate killing of the target cell. KIR genotyping may be useful in some stem cell transplants because KIR matching or mismatching can mediate a graft-versus-leukemia effect when the cancer cells are underexpressing HLA class I antigens.


Limitations

Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.


Methodology

A panel of sequence-specific oligonucleotide probes (SSOP) on fluorescently labeled microspheres (beads) with probes that target specific alleles


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
168141 Killer Immunoglobulin-like Rec 168142 2DL1 64413-8
168141 Killer Immunoglobulin-like Rec 168143 2DL2 64414-6
168141 Killer Immunoglobulin-like Rec 168144 2DL3 64415-3
168141 Killer Immunoglobulin-like Rec 168145 2DL4 64416-1
168141 Killer Immunoglobulin-like Rec 168151 2DL5 64419-5
168141 Killer Immunoglobulin-like Rec 168152 2DS1 64420-3
168141 Killer Immunoglobulin-like Rec 168156 2DS2 64421-1
168141 Killer Immunoglobulin-like Rec 168157 2DS3 64422-9
168141 Killer Immunoglobulin-like Rec 168159 2DS4 FUL 64423-7
168141 Killer Immunoglobulin-like Rec 168166 2DS4 DEL 64424-5
168141 Killer Immunoglobulin-like Rec 168167 2DS5 64425-2
168141 Killer Immunoglobulin-like Rec 168168 3DL1 64426-0
168141 Killer Immunoglobulin-like Rec 168169 3DL2 64427-8
168141 Killer Immunoglobulin-like Rec 168170 3DL3 64428-6
168141 Killer Immunoglobulin-like Rec 168171 3DS1 64429-4
168141 Killer Immunoglobulin-like Rec 168172 2DP1 64430-2
168141 Killer Immunoglobulin-like Rec 168173 3DP1 64431-0
168141 Killer Immunoglobulin-like Rec 167085 Comment: 49549-9

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf