Prenatal Infectious Disease Antibodies, Qualitative, IgG

TEST: 164101
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CPT: 86644; 86695; 86696; 86762; 86777
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Synonyms

  • CMV
  • HSV-1
  • HSV-2
  • Rubella
  • TORCH
  • Toxoplasma

Expected Turnaround Time

1 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum

Volume

1.0 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Storage Instructions

Refrigerate.

Causes for Rejection

Hemolysis; lipemia; grossly icteric; visible particulate matter; gross bacterial contamination

Test Details

Use

This test is used to detect TORCH antibodies and aid in the diagnosis of congenital infection.

Limitations

Serum samples collected too early in the course of infection may not have detectable levels of HSV IgG. In cases of suspected early disease, a repeat serum specimen should be collected 14-21 days later and submitted for testing.

The predictive value of positive or negative results depends on the prevalence of disease and the pretest likelihood of HSV-1 and HSV-2.

False-positive results may occur. Repeat testing, or testing by a different method, may be indicated in some settings (e.g., patients with low likelihood of HSV infection).

This test is intended for qualitative determination only. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample.

Methodology

Chemiluminescent immunoassay (CLIA)

References

American Academy of Pediatrics, American College of Obstetricians and Gynecologists. In: Kilpatrick SJ, Papile LA, eds. Guidelines for Perinatal Care, 8th Edition. ElkGrove, IL, and Washington, D.C.; 2017.
Landry LL. Immunoglobulin M for Acute Infection: True or False? Clin Vaccine Immuol. 2016 Jul 5;23(7):540-545.27193039
Miller JM, Binnicker MJ, Campbell S, et al. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the InfectiousDiseases Society of America and the American Society for Microbiology. Clin Infect Dis. 2018 Aug 31;67(6): e1-e94.29955859
US Preventive Services Task Force, Bibbins-Domingo K, Grossman DC, et al. Serologic Screening for Genital Herpes Infection: US Preventive Services Task ForceRecommendation Statement. JAMA. 2016 Dec 20;316(23):2525-2530.27997659
Workowski KA, Bachmann LH, Chan PH, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.34292926

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164101 Prenat Infect Dis Ab, IgG 164903 HSV 1 IgG, Type Spec index 5206-8
164101 Prenat Infect Dis Ab, IgG 164097 HSV 2 IgG, Type Spec index 5209-2
164101 Prenat Infect Dis Ab, IgG 006204 Rubella Antibodies, IgG index 5334-8
164101 Prenat Infect Dis Ab, IgG 006483 Toxoplasma gondii Ab,IgG IU/mL 5388-4
164101 Prenat Infect Dis Ab, IgG 006499 Cytomegalovirus (CMV) Ab, IgG U/mL 5124-3

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