Sexually Transmitted Infections (STI) Profile

CPT: 86592; 86704; 86706; 86803; 87340; 87389
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Synonyms

  • HBV
  • HCV
  • Hepatitis
  • HIV
  • Syphilis

Test Includes

RPR with reflex to quantitative RPR and confirmatory Treponema pallidum antibodies; HIV p24 Antigen/Antibody with reflex to confirmation; HBV screening and diagnosis (HBsAg, anti-HBs, HBc-total with reflex to IgM); HCV antibody with reflex to quantitative real-time PCR. If reflex testing is performed, additional charges/CPT code(s) may apply.


Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

If reflex test is performed, additional charges/CPT code(s) may apply.

HIV p24 Antigen/Antibody With Reflex to Confirmation [083935] requires a dedicated, unopened, gel-barrier tube or red-top tube sent directly to the testing facility.


Expected Turnaround Time

1 - 4 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

8 mL


Container

Gel-barrier tube


Collection

Usual blood collection technique


Storage Instructions

See individual test components.


Stability Requirements

Test Number

Sample Type

Room Temperature

Refrigerated

Frozen

Freeze/thaw Cycles

144473

Serum or plasma

14 days

14 days

14 days

Stable x3

144050

Serum or plasma

Antibody test: 24 hours

PCR test: 24 hours

Antibody test: 6 days

PCR test: 72 hours

Antibody test: 14 days

PCR test: 6 weeks

N/A

N/A

012005

Serum

14 days

14 days

14 days

Stable x3

083935

Serum

48 hours

14 days

14 days

Stable x5


Causes for Rejection

Gross hemolysis; gross lipemia; samples containing particulate matter or exhibiting obvious microbial contamination


Test Details


Use

Screen for and diagnose sexually transmitted infections and blood borne pathogens including syphilis, hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV. Testing aligns with current guidelines and recommendations.


Limitations

Some of the assays in this panel have not been FDA cleared or approved for the screening of blood or plasma donors, nor have assay performance characteristics been established for immunocompromised or immunosuppressed patients, cord blood, or patients less than 2 years of age.


Methodology

See individual test components.


References

AAP Committee on Fetus and Newborn and ACOG Committee on Obstetric Practice. Guidelines for Perinatal Care. Kilpatrick SJ, Papile LA, Macones GA, eds. 8th edition, September 2017.
Centers for Disease Control and Prevention (CDC). Hepatitis B. CDC website: www.cdc.gov/hepatitis/hbv/index.htm. Accessed March 2022.
Centers for Disease Control and Prevention (CDC), The American College of Obstetrics and Gynecologists. Screening and Referral Algorithm for Hepatitis B Virus (HBV) Infection Among Pregnant Women. CDC website: https://www.cdc.gov/hepatitis/hbv/pdfs/prenatalhbsagtesting_508.pdf. Accessed March 2022.
Schillie S, Vellozzi C, Reingold A, et al. Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2018; 67(1):1-31.29939980
U.S. Department of Health and Human Service. 2020. Sexually Transmitted Infections: National Strategic Plan for the United States 2021-2025. Washington, DC. Accessed March 2022 at https://www.hhs.gov/sites/default/files/STI-National-Strategic-Plan-2021-2025.pdf.
U.S. Preventive Services Task Force: Screening for Hepatitis B Virus Infection in Pregnant Women: Recommendation Statement. Am Fam Physician. 2020 Jan 15;101(2):112-114.31939639

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
144011 STI Profile 006510 HBsAg Screen 5196-1
144011 STI Profile 006408 Hep B Surface Ab, Qual 22322-2
144011 STI Profile 006718 Hep B Core Ab, Tot 13952-7
144011 STI Profile 006719 Rfx to HBc IgM 77202-0
144011 STI Profile 006720 Interpretation 56850-1
144011 STI Profile 144035 HCV Ab 40726-2
144011 STI Profile 006072 RPR 20507-0
144011 STI Profile 083936 HIV Ab/p24 Ag Screen 56888-1
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 016105 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex Table for Rfx to HBc IgM
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 016881 Hep B Core Ab, IgM 016881 Hep B Core Ab, IgM 24113-3
Reflex Table for HCV Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144030 Interpretation: 144030 Interpretation: 13955-0
Reflex Table for HCV Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 550362 HCV RT-PCR, Quant (Non-Graph) 550338 Hepatitis C Quantitation IU/mL 11011-4
Reflex 2 550352 HCV RNA (International Units) 550353 HCV RNA (International Units) IU/mL 11011-4
Reflex Table for HCV Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 550362 HCV RT-PCR, Quant (Non-Graph) 550338 Hepatitis C Quantitation IU/mL 11011-4
Reflex 2 550352 HCV RNA (International Units) 550354 HCV log10 log10 IU/mL 38180-6
Reflex Table for HCV Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 550362 HCV RT-PCR, Quant (Non-Graph) 550339 HCV log10 log10 IU/mL 38180-6
Reflex Table for HCV Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 550362 HCV RT-PCR, Quant (Non-Graph) 550314 Test Information: 19147-8
Reflex Table for HCV Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 550362 HCV RT-PCR, Quant (Non-Graph) 550396 Interpretation: 62365-2
Reflex Table for RPR
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 006464 RPR, Quant. 006464 RPR, Quant. titer 31147-2
Reflex Table for RPR
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 012021 RPR Qn+TP Abs 006464 RPR, Quant. titer 31147-2
Reflex Table for RPR
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 012021 RPR Qn+TP Abs 082371 Treponema pallidum Antibodies 47236-5
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083941 HIV 1 Ab 68961-2
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083942 HIV 2 Ab 81641-3
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083964 HIV-1/HIV-2 Qualitative RNA 139826 HIV-1 RNA 25835-0
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083964 HIV-1/HIV-2 Qualitative RNA 139827 HIV-2 RNA 69353-1
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083964 HIV-1/HIV-2 Qualitative RNA 083965 Final Interpretation 85380-4
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083964 HIV-1/HIV-2 Qualitative RNA 083944 HIV 1/2 Supplemental Ab Test N/A
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083962 HIV-1/HIV-2 Qualitative RNA 139826 HIV-1 RNA 25835-0
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083962 HIV-1/HIV-2 Qualitative RNA 139827 HIV-2 RNA 69353-1
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083962 HIV-1/HIV-2 Qualitative RNA 083963 Final Interpretation 85380-4
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083962 HIV-1/HIV-2 Qualitative RNA 083944 HIV 1/2 Supplemental Ab Test N/A
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083966 HIV-1/HIV-2 Qualitative RNA 139826 HIV-1 RNA 25835-0
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083966 HIV-1/HIV-2 Qualitative RNA 139827 HIV-2 RNA 69353-1
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083966 HIV-1/HIV-2 Qualitative RNA 083967 Final Interpretation 85380-4
Reflex Table for HIV Ab/p24 Ag Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 083940 HIV 1/2 Ab Differentiation 083954 Interpretation: 80203-3
Reflex 2 083966 HIV-1/HIV-2 Qualitative RNA 083944 HIV 1/2 Supplemental Ab Test N/A

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