Herpes Simplex Virus (HSV) Types 1/2, Cerebrospinal Fluid (CSF), DNA PCR

TEST: 139800
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CPT: 87529(x2)
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Synonyms

  • HSV PCR
  • HSV-1 PCR
  • HSV-2 PCR

Special Instructions

This test code is intended for cerebrospinal fluid (CSF) only.

Expected Turnaround Time

2 - 4 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Testing Options to Support Diagnosis and Screening of Herpes Simplex Virus (HSV)

Specimen Requirements

Specimen

Cerebrospinal fluid (CSF)

Volume

0.5 mL CSF

Minimum Volume

0.2 mL CSF

Container

Sterile container

Collection

To avoid delays in turnaround time when requesting multiple tests on frozen sample, please submit separate specimens for each test requested.

Storage Instructions

Frozen

Causes for Rejection

Improperly labeled or unlabeled specimen; specimen that has grossly leaked in transit; specimen submitted in an improper collection/transport device; non-CSF specimens

Test Details

Use

This assay is used for the detection and differentiation of HSV-1 and HSV-2 DNA in cerebrospinal fluid.

Limitations

Results from this test must be considered in conjunction with the clinical history, epidemiological data and other laboratory information available to the clinician evaluating the patient.

Negative results do not rule out HSV infections of the CNS and should not be used as the sole basis for treatment or other patient management decisions.

False-negative results may occur if the viruses are present at a level that is below the analytical sensitivity of the assay or if the virus has genomic mutations, insertions, deletions, or rearrangements or if performed very early in the course of illness.

For encephalitis patients with a negative herpes simplex PCR result, consideration should be given to repeating the test 3 - 7 days later for patients demonstrating a compatible syndrome or temporal lobe localization on neuroimaging.

Methodology

Real-time PCR

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
139800 HSV 1/2 PCR, CSF 32141-4 139801 HSV-1 DNA 16952-4
139800 HSV 1/2 PCR, CSF 32141-4 139802 HSV-2 DNA 16960-7

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