Find Locations
For hours, walk-ins and appointments.Chromosome Analysis With Reflex to SNP Microarray−Pediatric (Reveal®)
CPT:
Contact CPT coding department at 800-222-7566, ext 6-8400.
Synonyms
- aCGH
- CGH
- Chromosome RFX Microarray Pediatric/Adult
- High Resolution G-Banding
- Prometaphase Analysis
Special Instructions
Pertinent medical findings must accompany request. Call 800-345-4363 to request forms, or photocopy the Clinical Questionnaire for SNP Microarray from the Genetics Appendix online. This test may also be performed on adults.
When a child tested with this assay is found to have an abnormal array of unknown clinical significance that may be clarified through parental testing, there will be no charge associated with the follow-up parental testing that is based on the child's results. All other parental follow-up testing will be charged, including (but not limited to) autism susceptibility regions, known microdeletions/microduplications, autosomal recessive deletions/duplications, and large copy-number changes with likely pathogenic significance. The child's abnormal array results will indicate whether parental testing will be performed at no charge and will include the appropriate parental follow-up test number. For parental follow-up testing for arrays not performed at LabCorp, call 800-345-4363 to speak to a genetic counselor.
Expected Turnaround Time
14 - 25 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
For more information, please view the literature below.
Chromosome Microarray: A New High-density Allele-specific Diagnostic Platform
SNP Microarray Pediatric Clinical Questionnaire
Reveal℠ SNP Microarray: Pediatric
Reveal℠ SNP Microarray: Pediatría
Reveal℠ SNP Microarray: Revealing Answers to Complex Questions
Specimen Requirements
Specimen
Whole blood
Volume
6 mL (adults), 3 mL (pediatric)
Minimum Volume
2 mL
Container
Green-top (heparin) tube
Collection
Using sterile technique, collect 10 mL blood into a green-top (heparin) tube or syringe. Invert the tube several times to prevent coagulation. Specimens must be sent the same day as collected and arrive in the laboratory within 48 hours of venipuncture.
Storage Instructions
Maintain specimen at room temperature. Specimen may be refrigerated if there is a delay in shipment. Do not freeze.
Causes for Rejection
Hemolysis; clotted specimen; specimen more than 48 hours old; use of improper anticoagulant; frozen specimen
Test Details
Use
Detects microscopically visible chromosomal abnormalities and, if normal, SNP array reflex will detect chromosomal imbalances that could be associated with developmental delay/congenital anomalies.It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent.
Limitations
The SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Culture of cells in special medium; colcemid arrest of cells in prophase stage of mitosis following cell synchronization techniques. If cytogenetic analysis is normal, SNP microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052302 | Cells Counted | 62361-1 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052303 | Cells Karyotyped | 55199-4 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052304 | Cells Analyzed | 62360-3 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052305 | GTG Band Resolution Achieved | 62358-7 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052306 | Cytogenetic Diagnosis | 62356-1 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052014 | Cytogenetic Interpretation | 62357-9 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052308 | Specimen Type | 48002-0 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052015 | Director Review: | 48672-0 | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 052310 | Reflex | N/A | |
| 052045 | Chromosome RFX to Microarray | 62386-8 | 512123 | 51967-8 |
| Reflex Table for Reflex | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 052311 | Chromosome Microarray (CMA) | 052313 | Specimen Type | 31208-2 | |
| Reflex Table for Reflex | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 052311 | Chromosome Microarray (CMA) | 052314 | # of Genotyping Targets | N/A | |
| Reflex Table for Reflex | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 052311 | Chromosome Microarray (CMA) | 052315 | Array Type | N/A | |
| Reflex Table for Reflex | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 052311 | Chromosome Microarray (CMA) | 052317 | Diagnosis | 62357-9 | |
| Reflex Table for Reflex | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 052311 | Chromosome Microarray (CMA) | 052322 | Interpretation | 62365-2 | |
| Reflex Table for Reflex | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 052311 | Chromosome Microarray (CMA) | 052319 | Director Review: | 48672-0 | |
| Reflex Table for Reflex | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 052311 | Chromosome Microarray (CMA) | 512123 | 51967-8 | ||
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf