Allergy Components

IgE allergen component testing may be helpful in those cases wherein clinicians need to identify and quantify the IgE levels of the parts or components of a suspected, offending allergen that trigger genuine allergic sensitization and likely severe, systemic reaction and those that may produce cross-reactive sensitization and decreased clinical responsiveness.

Knowing this information may assist with management decisions, such as1:

  • Patient risk assessment and stratification for procedures such as food challenge testing,
  • Patient counseling on allergen exposure reduction and/or avoidance, or
  • Patient selection and selection of specific allergen(s) for immunotherapy.

As with any allergy testing, it is important to stress the importance of evaluating allergen component test results within the context of the patient’s history, as allergen IgE sensitization does not necessarily equate to clinical responsiveness; and each allergic patient responds individually to exposure to various allergen sources, creating his or her own distinct IgE antibody molecular “profile”.1

Below is a listing of frequently ordered individual allergens and profiles which include component reflexes. You can read a full description of each test by clicking on the test number in the table. A complete listing of allergen component testing and profiles can be found in our Food Component Allergen Testing Services brochure here and Tree Nut Allergen flyer here

Frequently Ordered Individual Allergens with Component Reflexes

Test Name

Test Number

Profile includes

Allergen Profile, Egg White, IgE With Component Reflexes*

603940

This test reflexes egg components Ovalbumin IgE and Ovomucoid IgE when the egg allergen-specific IgE is >0.35 kU/L.

Allergen Profile, Milk, IgE With Component Reflexes*

603927

This test reflexes milk components Alpha-lactaalbumin, Beta-lactoglobulin, and Casein IgE when the milk allergen-specific IgE is >0.35 kU/L.

Allergen Profile, Peanut, IgE With Component Reflexes*

603916

This test reflexes Peanut components Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9 when the peanut allergen-specific IgE is >0.10 kU/L.

Allergen Profile, Hazelnut, IgE With Component Reflexes*

604734

This test reflexes hazelnut components Cor a 1, Cor a 8, Cor a 9 and Cor a 14 when the hazelnut allergen-specific IgE is >0.10 kU/L.

Allergen Profile, Walnut, IgE With Component Reflex

604600

This test reflexes walnut components Jug r 1 and Jug r 3 when the walnut allergen-specific IgE is >0.10 kU/L.

Allergen Profile, Cashew Nut, IgE With Component Reflex*

604159

This test reflexes to cashew nut component Ana o 3 when the cashew allergen-specific IgE is >0.10 kU/L.

Allergen Profile, Brazil Nut, IgE With Component Reflexes*

603972

This test reflexes Brazil nut component Ber e 1 when the Brazil nut allergen-specific IgE is >0.10 kU/L.

 

Frequently Ordered Allergen Profiles that include Component Reflexes

Test Name

Test Number

Profile includes

Allergen Profile, IgE (Pediatric) With Component Reflexes* 

604771

Almond; Brazil nut; cashew nut; cat dander; Cladosporium herbarum; cockroach (German); codfish; D farina; D pteronyssinus; dog dander; egg white; hazelnut (filbert); macadamia nut; milk; mouse urine; peanut (whole); pecan; pistachio; scallop; sesame seed; shrimp; soybean; walnut; wheat

Allergen Profile Plus IgE (Pediatric) With Component Reflexes*  

603858

Alternaria alternate; cat dander; Cladosporium herbarum; cockroach (German); codfish; D farina; D pteronyssinus; dog dander; egg white; milk; mouse urine; peanut (whole); shrimp; soybean; walnut; wheat

Allergen Profile, Food-Basic IgE With Component Reflexes*   

603857

Codfish; cow’s milk; egg white; peanut (whole); soybean; wheat

Allergen Profile, Food IgE With Component Reflexes*   

603834

Clam; codfish; corn; egg white; milk; peanut (whole); scallop; sesame seed; shrimp; soybean; walnut; wheat

Allergen Profile, Food IgE II With Component Reflexes*  

604783

Almond; Brazil nut; cashew nut; clam; codfish; corn; egg white; hazelnut (filbert); macadamia nut; milk; peanut (whole); pecan; pistachio; scallop; sesame seed; shrimp; soybean; walnut; wheat

Allergen Profile, Nut, IgE With Component Reflexes*

604764

Almond, Brazil Nut, Cashew Nut, Hazelnut (Filbert), Macadamia Nut, Peanut (Whole), Pecan, Pistachio, Walnut

*If reflex testing is performed; additional charges/CPT code(s) may apply.

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