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To evaluate the hemoglobin content of your blood as part of a general health checkup; to screen for and help diagnose conditions that affect red blood cells (RBCs); if you have anemia (low hemoglobin) or polycythemia (high hemoglobin), to assess the severity of these conditions and to monitor response to treatment
With a hematocrit or as part of a complete blood count (CBC), which may be ordered as a component of a general health screen; when you have signs and symptoms of anemia (weakness, fatigue) or polycythemia (dizziness, headache); at regular intervals to monitor these conditions or response to treatment
A blood sample drawn from a vein or by a fingerstick (children and adults) or heelstick (newborns)
Hemoglobin is the iron-containing protein found in all red blood cells (RBCs) that gives the cells their characteristic red color. Hemoglobin enables RBCs to bind to oxygen in the lungs and carry it to tissues and organs throughout the body. It also helps transport a small portion of carbon dioxide, a product of cell metabolism, from tissues and organs to the lungs, where it is exhaled.
The hemoglobin test measures the amount of hemoglobin your sample of blood. A hemoglobin level can be performed alone or with a hematocrit, a test that measures the proportion of blood that is made up of RBCs, to evaluate your red blood cells. It is also one component of the complete blood count (CBC), a group of tests that are often used in the general evaluation of your health.
Red blood cells, which make up about 40% (ranging 37-49%) of the blood's volume, are produced in the bone marrow and are released into the bloodstream when they are, or nearly are, mature. The typical lifespan of an RBC is 120 days, and the bone marrow must continually produce new RBCs to replace those that age and degrade or are lost through bleeding.
Several diseases and conditions can affect RBCs and consequently the level of hemoglobin in the blood. In general, the hemoglobin level and hematocrit rise when the number of red blood cells increases. The hemoglobin level and hematocrit fall to less than normal when there is a decrease in RBCs.
Some conditions affect RBC production in the bone marrow and may cause an increase or decrease in the number of mature RBCs released into the blood circulation. Other conditions may affect the lifespan of RBCs in the circulation. If there is increased destruction of RBCs (hemolysis) or loss of RBCs through bleeding and/or the bone marrow is not able to produce new ones fast enough, then the overall number of RBCs and hemoglobin will drop, resulting in anemia.
Anemia is a condition in which tissues and organs in the body do not get enough oxygen, causing fatigue and weakness. If too many RBCs are produced, polycythemia results and the blood can become thickened, causing sluggish blood flow and related problems.
The hemoglobin test is often used to check for anemia, usually along with a hematocrit or as part of a complete blood count (CBC). The test may be used to screen for, diagnose, or monitor a number of conditions and diseases that affect red blood cells (RBCs) and/or the amount of hemoglobin in blood.
A hemoglobin test may be used to:
The hemoglobin test may be ordered as part of a CBC during a general health exam or when you have signs and symptoms of a condition affecting red blood cells such as anemia or polycythemia.
Some signs and symptoms of anemia include:
Some signs and symptoms of polycythemia include:
This test may be performed several times or on a regular basis when you have been diagnosed with ongoing bleeding problems or chronic anemia or polycythemia to determine the effectiveness of treatment. It may also be ordered routinely if you are undergoing treatment for cancer that is known to affect the bone marrow.
Since a hemoglobin level is often performed as part of a complete blood count (CBC), results from other components are taken into consideration. A rise or drop in the hemoglobin level must be interpreted in conjunction with other parameters, such as RBC count, hematocrit, reticulocyte count, and/or red blood cell indices. Age, sex, and race are other factors to be considered. In general, hemoglobin mirrors the results of the RBC count and hematocrit.
Low hemoglobin with low RBC count and low hematocrit indicates anemia. Some examples of causes include:
High hemoglobin with a high RBC count and high hematocrit indicates polycythemia. Some examples of causes include:
A recent blood transfusion can affect a person's hemoglobin level.
Hemoglobin decreases slightly during normal pregnancy.
Yes, there are some home tests currently available that have been approved by the U.S. Food and Drug Administration (FDA). Home testing offers many benefits, but it's also important to recognize the potential tradeoffs between quality and convenience and to take steps to protect yourself against the possibility of false results, and your own lack of training. Talk to your healthcare practitioner about this type of testing and discuss any questions or concerns you may have. For more about these tests, see the article With Home Testing, Consumers Take Charge of Their Health.
A hemoglobin test can indicate if there is a problem with red blood cell production and/or lifespan, but it cannot determine the underlying cause. In addition to the full CBC, some other tests that may be performed at the same time or as follow up to establish a cause include a blood smear, reticulocyte count, iron studies, vitamin B12 and folate levels, and in more severe conditions, a bone marrow examination.
Women of childbearing age tend to have lower hemoglobin levels than men due to loss of iron and blood during menstrual periods and increased need for iron during pregnancy. Others who are at greater risk of a low hemoglobin level (anemia) include people with poor nutrition and diets low in iron or vitamins, people who have undergone surgery or have been severely injured, people with chronic conditions such as kidney disease, cancer, HIV/AIDS, inflammatory bowel disease, chronic infection or chronic inflammatory conditions (e.g., rheumatoid arthritis). Someone who has family members with a genetic cause of anemia, such as sickle cell or thalassemia, also has a higher risk of having the condition and a higher risk of anemia.
Some warning signs are fatigue, fainting, pale skin (pallor), and shortness of breath.
Yes, to the extent that if you eat a well-balanced diet, you can prevent anemia due to a lack of iron, vitamin B12, or folate in the foods you eat. Sometimes use of a supplement is recommended if you are at risk of a vitamin deficiency. However, the most common cause of vitamin B12 deficiency is malabsorption, and the most common cause of iron deficiency is bleeding. These conditions and other red blood cell problems that are caused by diseases other than nutritional deficiencies cannot be corrected by diet.
Sources Used in Current Review
(October 7,2018) Maakaron, J. Anemia: Practice Essentials, Pathophysiology, Etiology. Medscape Reference. Available online at https://emedicine.medscape.com/article/198475-overview#a1. Accessed July 2019.
McPherson, Richard A & Pincus, Matthew R. (© 2017). Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd Edition: Elsevier Inc., St. Louis, MO. Chapter 32, 559-605.
Sources Used in Previous Reviews
Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].
Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.
Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 524-527.
Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2007, Chap 31, Pp 458, 489-491.
Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL eds (2005). Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp 329-336.
Pagana K, Pagana T. Mosby's Manual of Diagnostic and Laboratory Tests. 3rd Edition, St. Louis: Mosby Elsevier; 2006, Pp 300-303.
Harmening D. Clinical Hematology and Fundamentals of Hemostasis, Fifth Edition, F.A. Davis Company, Piladelphia, 2009, Pp 82-85, 771.
(Feb 9 2010) Dugdale D. Hemoglobin. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003645.htm. Accessed January 2012.
(December 2005) Mayo Reference Services. How to interpret and pursue an abnormal complete blood cell count in adults. Vol. 30 No. 12. PDF available for download at http://www.mayomedicallaboratories.com/media/articles/communique/mc2831-1205.pdf. Accessed January 2012.
(March 1, 2011) National Heart, Lung and Blood Institute. What is Polycythemia vera? Available online at http://www.nhlbi.nih.gov/health/public/blood/index.htm. Accessed Jan 2012.
(Aug 1, 2010) National Heart, Lung and Blood Institute. Anemia. Available online at http://www.nhlbi.nih.gov/health/health-topics/topics/anemia/. Accessed Jan 2012.
(November 4, 2011) Maarkaron J. Anemia. Medscape Reference article. Available online at http://emedicine.medscape.com/article/198475-overview. Accessed Jan 2012.
(May 26, 2011) Kahsai D. Emergent Management of Acute Anemia. Medscape Reference article. Available online at http://emedicine.medscape.com/article/780334-overview#a1. Accessed Jan 2012.
(August 26, 2011) Harper J. Pediatric Megaloblastic Anemia. eMedicine article. Available online at http://emedicine.medscape.com/article/959918-overview. Accessed Jan 2012.
(June 8, 2011) Artz A. Anemia in Elderly Persons. eMedicine article. Available online at http://emedicine.medscape.com/article/1339998-overview. Accessed Jan 2012.
Riley R, et.al. Automated Hematologic Evaluation. Medical College of Virginia, Virginia Commonwealth University. Available onlinr at http://www.pathology.vcu.edu/education/PathLab/pages/hematopath/pbs.html#Anchor-Automated-47857. Accessed Jan 2012.
Wintrobe's Clinical Hematology. 12th ed. Greer J, Foerster J, Rodgers G, Paraskevas F, Glader B, Arber D, Means R, eds. Philadelphia, PA: Lippincott Williams & Wilkins: 2009, Pg 4.
Harmening D, Clinical Hematology and Fundamentals of Hemostasis, Fifth Edition, F.A. Davis Company, Philadelphia, 2009, Pp 70, 771.
Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2011, 510-512, 557-599.
(Updated February 12, 2014) Yang B. Hemoglobin Concentration. Medscape Reference. Available online at http://emedicine.medscape.com/article/2085614-overview#a4. Accessed June 2015.