Different types of tests may be ordered to detect FIP1L1-PDGFRA. Samples may be analyzed using fluorescence in situ hybridization (FISH) or reverse transcription-polymerase chain reaction (RT-PCR). The FISH method uses fluorescent dye-labeled probes to detect the deletion of the portion of DNA (4q12, CHIC2 region) that results in the abnormal gene sequence, whereas the RT-PCR method directly detects the FIP1L1-PDGFRA gene sequence when it is present.
© 2017 American Association for Clinical Chemistry, republished from Lab Tests Online.*
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