Spotlight on RM-1: A syngeneic murine prostate gland carcinoma model
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Most prostate cancers are adenocarcinomas that develop from the gland cells that produce seminal fluid. The American Cancer Society's estimates are about 248,530 new cases in the United States for 2021, resulting in approximately 34,130 deaths.1 About 1 man in 8 will be diagnosed with prostate cancer during his lifetime and 1 in 41 will die of it. 1 Globally, prostate cancer is the second leading cause of cancer death in men, behind lung cancer.1 Fortunately, prostate cancer, when detected and treated early, has a nearly 100% estimated five-year survival rate for U.S. patients.2 Depending on the tumor stage, treatments can include active surveillance prostatectomy, beam radiation therapy, brachytherapy, hormone therapy, chemotherapy and treatments aimed at bone metastases in Stage IV cancers. To develop novel therapeutics, as monotherapies or in combination with clinical standards of care, testing in the most appropriate preclinical tumor model is key.