Glutathione, Total

CPT: 82978
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Expected Turnaround Time

4 - 7 days


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Specimen Requirements


Specimen

Whole blood


Volume

500 μL


Minimum Volume

100 μL


Container

Yellow-top ACD-B tube (acid citrate dextrose) or yellow-top ACD-A tube


Collection

Allow ACD tubes to fill completely; gently invert 8 to 10 times.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

7 days


Causes for Rejection

Blood collected in tubes other than ACD tubes; ACD collection tubes inadequately filled; hemolyzed specimens; clotted specimens


Test Details


Use

Glutathione is a tripeptide and is the primary regulator of cellular redox states. Glutathione exists primarily in its reduced form (GSH), which upon oxidation forms the dimer, glutathione disulfide (GSSG). GSH can also form disulfide bridges with proteins as a result of oxidation or enzyme catalyzed reactions, giving rise to protein-bound glutathione (GSSP). Decreased glutathione levels in whole blood have been associated with Parkinson's disease, HIV, liver disease, renal failure, as well as preëclampsia.


Limitations

Results of this test are for investigational purposes only. The performance characteristics of this assay have been determined by LabCorp. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.


Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
007700 Total Glutathione 91685-8 007701 Total Glutathione ug/mL 2383-8

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