Complement C2

CPT: 86160
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Synonyms

  • C2 Complement

Test Includes

Quantitation of antigenic (immunologic) C2


Expected Turnaround Time

6 - 11 days


Related Documents

For more information, please view the literature below.

Lupus Comprehensive Testing Brochure


Specimen Requirements


Specimen

Serum


Volume

2 mL


Minimum Volume

0.1 mL


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

12 days

Refrigerated

12 days

Frozen

12 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Excessive hemolysis; plasma specimen


Test Details


Use

Assess patients with hereditary deficiency of this component or acquired decrease in its level which may be seen due to hypercatabolism in hereditary angioneurotic edema, or consumption or loss as in vasculitides, glomerulonephritides, immune complex diseases. C2 deficiency is the most common complement deficiency (1 in 10,000) and is associated with SLE.


Limitations

Results of this test are labeled for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established by the manufacturer. The result should not be used for treatment or for diagnostic purposes without confirmation of the diagnosis by another medically established diagnostic product or procedure. The performance characteristics were determined by LabCorp.


Methodology

Immunologic quantitation by radial immunodiffusion (RID)


Reference Interval

1.4−3.3 mg/dL

*Reference interval has been verified for all age groups including pediatrics (birth to 18 years) and geriatrics.


Additional Information

Deficiencies of C1 components, C2 and C4 are associated with rheumatic diseases, including lupus, vasculitis, and dermatomyositis. Some individuals with deficiency may have no evidence of disease. The most common complement deficiency is C2, which is a homozygous abnormality in 1 in 10,000 to 40,000 individuals, and is heterozygous in 1% to 2% of the general population. Patients with C2 deficiency and lupus often have negative or low titer ANA.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
161414 Complement C2 4484-2 161415 Complement C2 mg/dL 4484-2

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