Estrone, Serum
| Estrone, Serum | | | |
| Number | | 004564 |
| CPT | | 82679 |
| Synonyms | | E1 |
| Special Instructions | | Nonpregnant patients only. |
| Specimen | | Serum or plasma |
| Volume | | 0.4 mL |
| Minimum Volume | | 0.2 mL (Note: This volume does not allow for repeat testing.) |
| Container | | Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube |
| Collection | | If a red-top tube or lavender-top tube is used, transfer separated serum or plasma to a plastic transport tube. |
| Storage Instructions | | Refrigerate |
| Patient Preparation | | No isotopes administered 24 hours prior to venipuncture. |
| Causes for Rejection | | Gross hemolysis; recently administered radioisotopes; lipemia; icteric specimen |
| Reference Interval | | See table.1,2,3
Age
(y) | Male
(pg/mL) | Female
(pg/mL) | | 0-5 | 18-53 | 19-46 | | 6-7 | 17-48 | 17-44 | | 8-9 | 20-54 | 31-70 | | 10-11 | 21-49 | 28-68 | | 12-14 | 17-44 | 57-140 | | Adults | 12-72 | Follicular phase: 37-138 | | Midcycle: 60-229 | | Luteal phase: 50-114 | | Postmenopausal: 14-103 | | Tanner Stage | | I | 5-17 | 4-29 | | II | 10-25 | 10-33 | | III | 15-25 | 15-43 | | IV | 15-45 | 16-77 | | V | 20-45 | 29-105 |
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| Use | | Evaluate postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion. |
| Methodology | | Radioimmunoassay (RIA) |
| Footnotes | | - Meites S, Buffone GJ, Cheng MH, et al, eds, Pediatric Clinical Chemistry, Reference (Normal) Values, 3rd ed, Washington, DC: AACC Press, 1989, 123.
- Ducharme JR, Forest MG, De Peretti E, et al, “Plasma Adrenal and Gonadal Sex Steroids in Human Pubertal Development,” J Clin Endocrinol Metab, 1976, 42(3):468-76.
- Tietz NW, ed, Clinical Guide to Laboratory Tests, 3rd ed, Philadelphia, PA: WB Saunders Co, 1995, 222
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| References | | Baird DT and Fraser IS, “Concentration of Oestrone and Oestradiol in Follicular Fluid and Ovarian Venous Blood in Women,” Clin Endocrinol (Oxf), 1975, 4(3):259-66. Wright K, Robinson H, Collins DC, et al, “Investigation of a Radioimmunoassay for Plasma Estrone and Estradiol-17-β in Male and Nonpregnant Females Comparison With an Independent Method Using Fluorometry,” J Clin Endocrinol Metab, 1973, 36(1):165-73. |
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