<i>Helicobacter pylori</i> Antibodies, IgA
| Helicobacter pylori Antibodies, IgA | | | |
| Number | | 163170 |
| CPT | | 86677 |
| Related Information | | Helicobacter pylori Antibodies, IgM |
| Synonyms | | Anti-Campylobacter Antibodies ; Anti-H. pylori, IgA |
| Specimen | | Serum |
| Volume | | 1 mL |
| Minimum Volume | | 0.5 mL |
| Container | | Red-top tube or gel-barrier tube |
| Storage Instructions | | Maintain specimen at room temperature. |
| Causes for Rejection | | Hemolysis; lipemia; gross bacterial contamination |
| Reference Interval | | - Negative: <0.89 index
- Equivocal: 0.89-0.99 index
- Positive: >0.99 index
|
| Use | | Diagnose H. pylori infection in patients with duodenal disease and for monitoring the eradication of H. pylori following antimicrobial therapy; identify the small percentage of H. pylori-infected patients who fail to mount a systemic IgG response and demonstrate IgA antibodies only and for those patients who have chronic mucosal infections |
| Methodology | | Enzyme immunoassay (EIA) |
| Additional Information | | Circulating antibodies to H. pylori are predominantly of the IgG class. A systemic response of the IgA type is usually less pronounced but, if significant, may indicate a more severe inflammation. A few patients develop only antibodies to IgA. IgM antibodies are rarely found and appear to be of minor importance. |
| References | | Kosunen TU, Seppala K, Sarna S, et al, “Diagnostic Value of Decreasing IgG, IgA, and IgM Antibody Titers After Eradication of Helicobacter pylori,” Lancet, 1992, 339(8798):893-5. Thomson A, “Helicobacter pylori and Gastroduodenal Pathology,” Can J Gastroenterol, 1993, 7:353-8. von Wulffen H, “An Assessment of Serological Tests for the Detection of Helicobacter pylori,” Eur J Clin Microbiol Infect Dis, 1992, 11(7):577-82 (review). |
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