Creatine, Serum      Number 002402 CPT 82540 Special Instructions State patient's sex on the request form. Specimen Serum, frozen Volume 2 mL Minimum Volume 0.2 mL Container Red-top tube Collection Separate serum from red cells. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested. Storage Instructions Freeze Causes for Rejection Hemolysis; specimen not frozen Reference Interval Male: 0.2-0.7 mg/dL; female: 0.3-0.9 mg/dL Use Serum creatine levels may be significantly increased in amyotrophic lateral sclerosis, dermatomyositis, myasthenia gravis, starvation, muscular dystrophies, and trauma. Creatine synthesis is stimulated by methyltestosterone and may also be increased in hyperthyroidism, diabetic acidosis, and puerperium. Methodology Enzymatic (creatinase)/spectrophotometry Additional Information Creatine is transported from the sites of synthesis (kidney, liver, pancreas) via the circulatory system to muscle and brain tissue where it is phosphorylated to phosphocreatine. Phosphocreatine and creatine are rapidly interconverted during muscle contraction. Approximately 1% to 2% of free creatine in muscle is converted to creatinine daily.

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