Lactic Acid Dehydrogenase (LD), Body Fluid
| Lactic Acid Dehydrogenase (LD), Body Fluid | | | |
| Number | | 100156 |
| CPT | | 83615 |
| Synonyms | | Lactate Dehydrogenase, Variable ; LD, Body Fluid ; LD, Fluid ; LD Variable |
| Specimen | | Fluid or cerebrospinal fluid |
| Volume | | 1 mL fluid or 1 mL CSF |
| Minimum Volume | | 0.3 mL |
| Container | | Sterile body fluid container |
| Storage Instructions | | Maintain specimen at room temperature. |
| Causes for Rejection | | Improper labeling |
| Use | | A fluid LD activity nearly equal to the plasma activity is usually associated with inflammatory processes |
| Methodology | | Kinetic |
| Additional Information | | Lactate dehydrogenase (LD) is a normal component of CSF. Increased amounts may occur in association with ischemic necrosis, meningitis, leukemia, metastatic cancer of the CNS, and lymphoma. LDH1 and LDH2 are decreased in lavage fluid in pulmonary alveolar proteinosis.1 One application of LD measurement is the differential diagnosis of intracranial hemorrhage in neonates versus traumatic tap. Lactate dehydrogenase is elevated in proportion to severity of CNS hemorrhage, but unchanged by traumatic tap. CSF LDH is higher in stroke than in transient ischemic attack.2 |
| Footnotes | | - Hoffman RM and Rogers RM, “Serum and Lavage Lactate Dehydrogenase Isoenzymes in Pulmonary Alveolar Proteinosis,” Am Rev Respir Dis, 1991, 143(1):42-6.
- Lampl Y, Paniri Y, Eshel Y, et al, “Cerebrospinal Fluid Lactate Dehydrogenase Levels in Early Stroke and Transient Ischemic Attacks,” Stroke, 1990, 21(6):854-7
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