Serum Integrated 1

Serum Integrated 1

Number
	017200
CPT
	84163
Related Information
	Serum Integrated 2 (017270)
Synonyms
	PAPP-A; Down Syndrome; Serum
Special Instructions
	Test inquiries call CMBP Genetic Services at 800-345-GENE. The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's race, patient's weight, patient's date of birth, patient's insulin dependent diabetic status and the number of fetuses. Also indicate patient history (ie prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing provided from 10.0 to 13.9 weeks gestation.
Specimen
	Serum
Volume
	3 mL
Minimum Volume
	1 mL
Container
	Gel-barrier tube, no thrombin additive
Collection
	Avoid hemolysis; send complete specimen in the original tube. Do not pour off.
Storage Instructions
	Refrigerate
Causes for Rejection
	Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type
Use
	Screening test for open neural tube defects, Down Syndrome, and Trisomy 18.
Limitations
	Serum Integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.
Methodology
	Enzyme Immunoassay (EIA)
References
	Wald NJ, Watt HC, Hackshaw AK. Integrated Screening for Down's Syndrome Based on Tests Performed During the First and Second Trimesters. New Eng. J. Med, 1999; 341(7): 461-467.