Hepatitis Be Antibody

Hepatitis Be Antibody

Number
	006635
CPT
	86707
Synonyms
	Antibody to Hepatitis Be Antigen ; Anti-HBe ; HBeAb
Specimen
	Serum
Volume
	1 mL
Minimum Volume
	0.4 mL (Note: This volume does not allow for repeat testing.)
Container
	Red-top tube or gel-barrier tube
Collection
	If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
	Refrigerate
Causes for Rejection
	Plasma specimen
Reference Interval
	Negative
Use
	Differential diagnosis, staging, and prognosis of hepatitis B infection
Methodology
	Enzyme immunoassay (EIA)
Additional Information
	The appearance of anti-HBe in patients who have previously been HBeAg positive indicates a reduced risk of infectivity. Failure of appearance implies disease activity and probable chronicity but patients with HBeAb may have chronic hepatitis. Chronic HBsAg carriers can be positive for either HBeAg or anti-HBe, but are less infectious when anti-HBe is present. HBe can persist for years, but usually disappears earlier than anti-HBs or anti-HBc. Anti-HBe has not been found as the sole serologic marker for hepatitis B infection. See figure in Hepatitis B Core Antibody, IgM [016881] .
References
	Bortolotti F, Calzia R, Cadrobbi P, et al, “Long-Term Evolution of Chronic Hepatitis B in Children With Antibody to Hepatitis Be Antigen,” J Pediatr, 1990, 116(4):552-5. Edwards MS, “Hepatitis B Serology - Help in Interpretation,” Pediatr Clin North Am, 1988, 35(3):503-15 (review). Mushahwar IK, Dienstag JL, Polesky HF, et al, “Interpretation of Various Serological Profiles of Hepatitis B Virus Infection,” Am J Clin Pathol, 1981, 76(6):773-7. Mushahwar IK, McGrath LC, Drnec J, et al, “Radioimmunoassay for Detection of Hepatitis Be Antigen and its Antibody. Results of Clinical Evaluation,” Am J Clin Pathol, 1981, 76(5):692-7. Okada K, Kamiyama I, Inomata M, et al, “e Antigen and Anti-e in the Serum of Asymptomatic Carrier Mothers as Indicators of Positive and Negative Transmission of Hepatitis B Virus to Their Infants,” N Engl J Med, 1976, 294(14):746-9.