Alpha-Fetoprotein (AFP), Maternal Serum for Open Spina Bifida      Number 010801 CPT 82105 Synonyms AFP, Maternal Serum ; Maternal Serum Alpha-Fetoprotein ; msAFP Special Instructions This test screens for open spina bifida. This test does not screen for Down syndrome or trisomy 18. The following information must be provided: gestational age, date on which the patient was the stated gestation age, how gestational age was determined (LMP, EDD, US), patient's weight, patient's date of birth, patient's race (white, black, other), and insulin-dependent diabetic status. Also indicate relevant patient history, such as prior neural tube defects, ultrasound anomalies, or previous maternal serum screening during this pregnancy. Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition form 0900. Specimens must be collected before amniocentesis. Specimen Serum Volume 3 mL Container Gel-barrier tube, no thrombin additive Collection Separate serum from cells. Avoid hemolysis. Send complete specimen in the original tube. Do not pour off. Storage Instructions Refrigerate Patient Preparation Open spina bifida screening is offered for gestational ages 15-23 weeks. The optimal gestational age for open spina bifida screening is 16-18 weeks. Causes for Rejection Gross hemolysis; gross lipemia; quantity not sufficient for analysis Use Screening test for open neural tube defects. Detects 80% of open spina bifida and 90% of anencephaly. Please note that this test does not provide screening for Down syndrome or trisomy 18. Methodology Immunochemiluminometric assay (ICMA)

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