Causes of Abnormal Screening - Factor Deficiencies


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Causes of Abnormal Screening Results

Causes of Abnormal Screening Results | Specimen Collection and Transport Issues | Medication | Pathologic Conditions | Factor Deficiencies | Factor Inhibitors

Factor Deficiencies

Factor Deficiency	Cases per Million Individuals¹	Screening Tests	Specific Factor Level Test Number	Comments
vWF	>100	vWF Profile	084715	aPTT can sometimes be extended. The aPTT should not be used to screen for von Willebrand disease (vWD) although it can sometimes be prolonged in vWD.
XII		aPTT	086322	It should be noted that factor XII deficiency is quite common but is not associated with bleeding.
VIII	60-100	aPTT	086264	Affects males predominantly. Congenital factor VIII deficiency (hemophilia A) affects males predominantly; factor VIII is often decreased in vWD. vWD has an autosomal mode of inheritance and, therefore, affects both sexes.
IX	10-20	aPTT	086298	Affects males predominantly.
XI	1	aPTT		Congenital factor XI deficiency (hemophilia C) has an autosomal mode of inheritance and, therefore, affects both sexes.
Fibrinogen	1	aPTT, PT	001610
II	<0.5	aPTT, PT	086231
V	<0.5	aPTT, PT	086249	The PT is generally more sensitive to deficiency of factor V than is the aPTT.
VII	<0.5	PT	800599
X	<0.5	aPTT, PT	086306	The PT is generally more sensitive to deficiency of factor X than is the aPTT.
XIII	<0.5		086330	Both PT and aPTT will be normal. Must test directly

More information about clinical aspects and testing for individual factor deficiencies can be found under the individual test descriptions.

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